FLT3-IN-29
FLT3-IN-29 (Compound MY-10) is a FLT3 inhibitor (IC50s: 6.5 and 10.3 nM for FLT3-ITD and FLT3-D835Y mutants). FLT3-IN-29 arrests cell cycle at the G0/G1 phase and efficiently induces Apoptosis. FLT3-IN-29 also reduces reactive oxygen species (ROS) production and mitochondrial membrane potential (MMP). FLT3-IN-29 displays antileukemic activity.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C25H30N6O2
- Molecular Weight:446.54
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
FLT3-IN-29 shows good antiproliferative activity against MV4-11 cells (IC50 = 0.59 μM)[1].
FLT3-IN-29 (0.2-10 μM, 24 h) arrests cell cycle at the G0/G1 phase, induces•apoptosis, and reduces ROS levels in MV4-11 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Molecular Weight 446.54
-
Formel C25H30N6O2
-
SMILES
CC(C)N1CCC(NC2=NC(NC3=CC=C(OC4=CC=CC=C4)C=C3)=C(C(N)=O)C=N2)CC1
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
FLT3-IN-29 Related Classifications
HY-170640 Related Classifications
Powered by Bioz