Art. -Nr.: HY-14769

Folitixorin

Name: Folitixorin
Brand: MedChemExpress
SKU: HY-14769
Price: 280.00 USD
Availability: InStock
Rating: 5 (2 reviews)

(Synonyms: 5,10-Methylenetetrafolate; ANX-510 free acid)

2 Cited Publications

Kundenbewertung

Based on 2 publication(s) in Google Scholar

Folitixorin (5,10-Methylenetetrafolate; ANX-510 free acid) is a reduced form of Folic acid (HY-16637) and a cofactor of thymidylate synthase. Folitixorin acts as an essential cofactor to promote the formation of a tight ternary complex between thymidylate synthase and FdUMP, thereby enhancing the inhibitory effect of FdUMP on thymidylate synthase. Folitixorin in combination with 5-fluorouracil and αVEGF reduces tumor volume in colorectal tumor models of nude mice. Folitixorin is used in related research on Yoshida sarcoma, P-388 leukemia, and colorectal cancer.

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Reinheit : 83.37%
CAS. Nr.: 3432-99-3
Formel: C₂₀H₂₃N₇O₆
Molecular Weight:457.44

Speicherung:

Shipping with dry ice

-80°C, protect from light, stored under nitrogen

Folitixorin Chemical Structure

CAS. Nr.: 3432-99-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Bacterial Infection

Folitixorin (1000 ns) forms structurally conserved stable complexes with human thymidylate synthase and Klebsiella pneumoniae thymidylate synthase ^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Folitixorin (0.6 mg/mouse; i.p.; once daily for five consecutive days) in combination with 5‑Fluorouracil and αVEGF reduces tumor volume and improves survival rate in a colorectal tumor model of nude mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

6-8 week old nude mice (nu/nu) with 2 x 10⁶ HT-29 cells^[3]
Dosage:

0.6 mg/mouse/drug ( 5-FU, Leucovorin, and αVEGF)
Administration:

i.p., daily, five consecutive days with the exception of αVEGF, dosed once (100 μg/mouse) on day 1
Result:

Reduced tumor volume and improved survival rate in a colorectal tumor model of nude mice.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

Chemical Information

CAS. Nr. 3432-99-3
Appearance Solid
Molecular Weight 457.44
Formel C₂₀H₂₃N₇O₆
Color White to yellow
SMILES

O=C1C2=C(NCC3N2CN(C4=CC=C(C(N[C@]([H])(C(O)=O)CCC(O)=O)=O)C=C4)C3)NC(N)=N1
Synonyms

5,10-Methylenetetrafolate; ANX-510 free acid
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Versand

Shipping with dry ice.
Speicherung

-80°C, protect from light, stored under nitrogen

Publications (2)

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Journal Impact Factor

Nat Commun

Nuclear localization of MTHFD2 is required for correct mitosis progression. [Abstract]

2024 Nov 12;15(1):9529. PMID: 39532843
bioRxiv

2023 Jun 1.

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 5 mg/mL (10.93 mM; ultrasonic and warming and heat to 60°C)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1861 mL

10.9304 mL

21.8608 mL

5 mM

0.4372 mL

2.1861 mL

4.3722 mL

10 mM

0.2186 mL

1.0930 mL

2.1861 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (285 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Shirasaka T, et al. Metabolic basis of the synergistic antitumor activities of 5-fluorouracil and cisplatin in rodent tumor models in vivo. Cancer chemotherapy and pharmacology. 1993;32(3):167-72.

[2]. Chen YL, et al. Artificial intelligence-guided discovery of a lead compound with antifolate-like activity against bacterial and human thymidylate synthases. Frontiers in cellular and infection microbiology. 2026;16:1816809. [Content Brief]

[3]. M. J. Cantwell et al. Antitumor activity of combination 5,10-methylenetetrahydrofolate, 5-fluorouracil, and anti-vascular endothelial growth factor against human colorectal HT-29 tumors in nude mice. J Clin Oncol 22, 3768-3768(2004).

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	2.1861 mL	10.9304 mL	21.8608 mL	54.6520 mL
	5 mM	0.4372 mL	2.1861 mL	4.3722 mL	10.9304 mL
	10 mM	0.2186 mL	1.0930 mL	2.1861 mL	5.4652 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Bioz

Keywords

Folitixorin

2 Cited Publications

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Folitixorin

Publications Citing Use of MedChemExpress (MCE) Folitixorin