MED6 - mediator complex subunit 6 Gene

Also Known as ARC33; NY-REN-28

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10001

About MED6

Cytogenetic location: 14q24.2 Genomic coordinates (GRCh38): 14:70,583,221-70,600,655 (from NCBI)

This gene has 12 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in lymph node (RPKM 6.4), ovary (RPKM 5.9) and 25 other tissues.

Summary

Enables transcription coactivator activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of mediator complex. [provided by Alliance of Genome Resources, Apr 2022]

MED6 Products (4)

mRNA Protein Name
NM_001284209.2 NP_001271138.1 mediator of RNA polymerase II transcription subunit 6 isoform 1
NM_001284210.2 NP_001271139.1 mediator of RNA polymerase II transcription subunit 6 isoform 3
NM_001284211.2 NP_001271140.1 mediator of RNA polymerase II transcription subunit 6 isoform 4
NM_005466.4 NP_005457.2 mediator of RNA polymerase II transcription subunit 6 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
14576168 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
12037571 GOA
enables transcription coactivator binding IPI
IPI: Inferred from physical interaction
17641689 GOA
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12037571 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of core mediator complex IPI
IPI: Inferred from physical interaction
24882805 GOA
part of mediator complex IDA
IDA: Inferred from direct assay
12037571 GOA
part of mediator complex IMP
IMP: Inferred from mutant phenotype
17641689 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24882805 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED6 Protein Structure

Med6

Med6: MED6 mediator sub complex component (13 - 141)

  • 0
  • 100
  • 200
  • 246 a.a.
Protein Preferred Names Protein Names

mediator of RNA polymerase II transcription subunit 6

  • CTD-2540L5.5

MED6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
MED6 O75586 CUL1 Homo sapiens Q13616
Anti Bait CoIP
22479149
Intra
MED6 O75586 MED17 Homo sapiens Q9NVC6
Anti Tag CoIP
24882805
Intra
MED6 O75586 MED17 Homo sapiens Q9NVC6
Anti Tag CoIP
35271311
Intra
MED6 O75586 MED27 Homo sapiens Q6P2C8
Anti Tag CoIP
24882805
Intra
MED6 O75586 MED27 Homo sapiens Q6P2C8
Anti Tag CoIP
35271311
Cross
MED6 O75586 Med20 Mus musculus Q9R0X0
Anti Tag CoIP
24882805
Intra
MED6 O75586 MED28 Homo sapiens Q9H204
Anti Tag CoIP
24882805
Intra
MED6 O75586 MED28 Homo sapiens Q9H204
Anti Tag CoIP
35271311
Cross
MED6 O75586 Med8 Mus musculus Q9D7W5
Anti Tag CoIP
24882805
Cross: Cross-species interaction Intra: Intraspecies interaction

MED6 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P810039 Med6 Antibody (YA9383) WB, IP, ELISA human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS08304 MED6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-169233 MED6-189 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MED6 MGD MGI:1917042
Canis familiaris MED6 VGNC VGNC:43140
Rattus norvegicus MED6 RGD RGD:1310296
Macaca mulatta MED6 VGNC VGNC:74539
Felis catus MED6 VGNC VGNC:80916
Bos taurus MED6 VGNC VGNC:31369
Others MED6 NCBI