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TADA3 - transcriptional adaptor 3 Gene

Also Known as ADA3; NGG1; hADA3; STAF54; TADA3L

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10474

About TADA3

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:9,779,967-9,793,011 (from NCBI)

This gene has 6 transcripts (splice variants) and 218 orthologues. Ubiquitous expression in testis (RPKM 21.9), ovary (RPKM 20.9) and 25 other tissues.

Summary

DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Along with the Other components of the complex, this protein links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional machinery. The protein is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

TADA3 Products (3)

mRNA	Protein	Name
NM_001278270.2	NP_001265199.1	transcriptional adapter 3 isoform a
NM_006354.5	NP_006345.1	transcriptional adapter 3 isoform a
NM_133480.4	NP_597814.1	transcriptional adapter 3 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables nuclear receptor binding	IPI IPI: Inferred from physical interaction	20413580	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15383276	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	20413580	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	11564863	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18838386	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20413580	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20413580	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19936620	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	19103755	GOA
involved in regulation of cell division	IDA IDA: Inferred from direct assay	20562830	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9603525	GOA
involved in regulation of tubulin deacetylation	IMP IMP: Inferred from mutant phenotype	20562830	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of ATAC complex	IDA IDA: Inferred from direct assay	18838386	GOA
part of SAGA complex	IDA IDA: Inferred from direct assay	11564863	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11564863	GOA
part of transcription factor TFTC complex	IDA IDA: Inferred from direct assay	10373431	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TADA3 Protein Structure

Ada3

0
100
200
300
400
432 a.a.

Protein Preferred Names	Protein Names
transcriptional adapter 3	ADA3 homolog

TADA3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	TADA3	O75528	ANKRD36B	Homo sapiens	Q8N2N9-4	Validated Y2H	32296183
Cross	TADA3	O75528	Dclk3	Mus musculus	Q8BWQ5	Anti Tag CoIP	29534157
Intra	TADA3	O75528	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	TADA3	O75528	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	TADA3	O75528	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	TADA3	O75528	AATF	Homo sapiens	Q9NY61	Y2H	29232376
Intra	TADA3	O75528	PIAS4	Homo sapiens	Q8N2W9	Pull Down	15383276
Intra	TADA3	O75528	PIAS4	Homo sapiens	Q8N2W9	Y2H	15383276
Intra	TADA3	O75528	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	TADA3	O75528	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	TADA3	O75528	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	TADA3	O75528	HEXIM2	Homo sapiens	Q96MH2	Y2H Prey Pooling	25416956
Intra	TADA3	O75528	TXLNB	Homo sapiens	Q8N3L3	Validated Y2H	32296183
Intra	TADA3	O75528	ICAM5	Homo sapiens	Q9UMF0	Y2H Array	32814053
Intra	TADA3	O75528	ICAM5	Homo sapiens	Q9UMF0	Validated Y2H	32814053
Intra	TADA3	O75528	ICAM5	Homo sapiens	Q9UMF0	Y2H Pooling	32814053
Intra	TADA3	O75528	STX11	Homo sapiens	O75558	Validated Y2H	32296183
Intra	TADA3	O75528	USP5	Homo sapiens	P45974	Pull Down	16189514
Intra	TADA3	O75528	USP5	Homo sapiens	P45974	Y2H Pooling	16189514
Intra	TADA3	O75528	TADA2A	Homo sapiens	O75478	Anti Tag CoIP	33961781
Intra	TADA3	O75528	TADA2A	Homo sapiens	O75478	Anti Tag CoIP	22644376
Intra	TADA3	O75528	SGF29	Homo sapiens	Q96ES7	Y2H Pooling	16189514
Intra	TADA3	O75528	SGF29	Homo sapiens	Q96ES7	Y2H Prey Pooling	25416956
Intra	TADA3	O75528	SGF29	Homo sapiens	Q96ES7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spinocerebellar Ataxia 7	Spinocerebellar Ataxia Type 7 SCA7 Opca3 Opca Iii Olivopontocerebellar Atrophy Iii Opca With Retinal Degeneration Opca With Macular Degeneration And External Ophthalmoplegia Adca, Type Ii Autosomal Dominant Cerebellar Ataxia Type 2 Olivopontocerebellar Atrophy 3 Autosomal Dominant Cerebellar Ataxia, Type Ii Autosomal Dominant Cerebellar Ataxia Type Ii Adca2 Adcaii Ataxia With Pigmentary Retinopathy Cerebellar Syndrome-Pigmentary Maculopathy Syndrome Olivopontocerebellar Atrophy With Retinal Degeneration Spinocerebellar Ataxia-7 Ataxia, Spinocerebellar, Type 7
Epidermodysplasia Verruciformis 1	Epidermodysplasia Verruciformis Epidermodysplasia Verruciformis, Susceptibility To, 1 Lutz-Lewandowsky Epidermodysplasia Verruciformis EV1 Lewandowsky-Lutz Syndrome Ev

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS14156	TADA3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20499	Tada3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27007	Tada3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TADA3	VGNC	VGNC:35566
Macaca mulatta	TADA3	VGNC	VGNC:78171
Canis familiaris	TADA3	VGNC	VGNC:47072
Mus musculus	TADA3	MGD	MGI:1915724
Rattus norvegicus	TADA3	RGD	RGD:1564009
Felis catus	TADA3	VGNC	VGNC:65924
Others	TADA3	NCBI