KIF2C - kinesin family member 2C Gene

Also Known as MCAK; CT139; KNSL6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11004

About KIF2C

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:44,739,837-44,767,767 (from NCBI)

This gene has 8 transcripts (splice variants), 127 orthologues and 41 paralogues. Biased expression in testis (RPKM 39.1), bone marrow (RPKM 9.5) and 6 other tissues.

Summary

This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

KIF2C Products (4)

mRNA Protein Name
NM_001297655.2 NP_001284584.1 kinesin-like protein KIF2C isoform 2
NM_001297656.2 NP_001284585.1 kinesin-like protein KIF2C isoform 3
NM_001297657.2 NP_001284586.1 kinesin-like protein KIF2C isoform 4
NM_006845.4 NP_006836.2 kinesin-like protein KIF2C isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables microtubule plus-end binding IDA
IDA: Inferred from direct assay
19632184 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11092768 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in attachment of mitotic spindle microtubules to kinetochore IMP
IMP: Inferred from mutant phenotype
23891108 GOA
involved in establishment or maintenance of microtubule cytoskeleton polarity IMP
IMP: Inferred from mutant phenotype
14718566 GOA
involved in metaphase chromosome alignment IMP
IMP: Inferred from mutant phenotype
23891108 GOA
involved in microtubule depolymerization IDA
IDA: Inferred from direct assay
21820309 GOA
involved in microtubule depolymerization IMP
IMP: Inferred from mutant phenotype
19060894 GOA
involved in mitotic metaphase chromosome alignment IMP
IMP: Inferred from mutant phenotype
15843429 GOA
involved in regulation of chromosome segregation IMP
IMP: Inferred from mutant phenotype
19060894 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in chromosome, centromeric region IDA
IDA: Inferred from direct assay
14960279 GOA
colocalizes with kinetochore IDA
IDA: Inferred from direct assay
14960279 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
23891108 GOA
located in microtubule plus-end IDA
IDA: Inferred from direct assay
21820309 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF2C Protein Structure

Kinesin

Kinesin: Kinesin motor domain (264 - 587)

  • 0
  • 200
  • 400
  • 600
  • 725 a.a.
Protein Preferred Names Protein Names

kinesin-like protein KIF2C

  • kinesin-like protein 6

KIF2C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
KIF2C Q99661 MAPRE1 Homo sapiens Q15691
Pull Down
19632184
Intra
KIF2C Q99661 MAPRE1 Homo sapiens Q15691
Pull Down
19543227
Intra
KIF2C Q99661 MTUS2 Homo sapiens Q5JR59
IF
19543227
Intra
KIF2C Q99661 MTUS2 Homo sapiens Q5JR59
Pull Down
19543227
Intra
KIF2C Q99661 SGF29 Homo sapiens Q96ES7
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

KIF2C Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P811104 Phospho-KIF2C (Ser95) Antibody WB, IHC-P, ICC/IF Human, Monkey
HY-P82669 MCAK Antibody (YA2414) WB, ICC/IF, FC Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-173522 KIF2C-IN-1 98.08% Unkown
HY-RS07284 KIF2C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20434 Kif2c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26943 Kif2c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus KIF2C VGNC VGNC:30601
Felis catus KIF2C VGNC VGNC:67974
Mus musculus KIF2C MGD MGI:1921054
Macaca mulatta KIF2C VGNC VGNC:74034
Rattus norvegicus KIF2C RGD RGD:620239
Canis familiaris KIF2C VGNC VGNC:42403
Others KIF2C NCBI