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GUCA2A - guanylate cyclase activator 2A Gene

Also Known as GUCA2; STARA; GCAP-I

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2980

About GUCA2A

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:42,162,690-42,164,745 (from NCBI)

This gene has 1 transcript (splice variant), 143 orthologues and 1 paralogue. Biased expression in small intestine (RPKM 352.1), colon (RPKM 198.7) and 1 other tissue.

Summary

Predicted to enable Guanylate Cyclase Activator activity. Predicted to be involved in positive regulation of Guanylate Cyclase activity and signal transduction. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

GUCA2A Products (1)

mRNA	Protein	Name
NM_033553.3	NP_291031.2	guanylin precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GUCA2A Protein Structure

Guanylin

0
100
115 a.a.

Protein Preferred Names	Protein Names
guanylin	guanylate cyclase activator 2A (guanylin 2, intestinal, heat-stable)

GUCA2A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	GUCA2A	Q02747	NEMP1	Homo sapiens	O14524-2	Y2H Array	32296183
Intra	GUCA2A	Q02747	NEMP1	Homo sapiens	O14524-2	Y2H Prey Pooling	32296183
Intra	GUCA2A	Q02747	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	GUCA2A	Q02747	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	GUCA2A	Q02747	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	GUCA2A	Q02747	TMEM179B	Homo sapiens	Q7Z7N9	Validated Y2H	32296183
Intra	GUCA2A	Q02747	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Array	32296183
Intra	GUCA2A	Q02747	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Prey Pooling	32296183
Intra	GUCA2A	Q02747	ASPH	Homo sapiens	Q12797-6	Validated Y2H	32296183
Intra	GUCA2A	Q02747	SLC34A2	Homo sapiens	O95436-2	Y2H Prey Pooling	32296183
Intra	GUCA2A	Q02747	SLC34A2	Homo sapiens	O95436-2	Y2H Array	32296183
Intra	GUCA2A	Q02747	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	GUCA2A	Q02747	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	GUCA2A	Q02747	TRAM1	Homo sapiens	Q15629	Y2H Prey Pooling	32296183
Intra	GUCA2A	Q02747	TRAM1	Homo sapiens	Q15629	Validated Y2H	32296183
Intra	GUCA2A	Q02747	TRAM1	Homo sapiens	Q15629	Y2H Array	32296183
Intra	GUCA2A	Q02747	TMEM86B	Homo sapiens	Q8N661	Y2H Prey Pooling	32296183
Intra	GUCA2A	Q02747	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
Intra	GUCA2A	Q02747	TMEM86B	Homo sapiens	Q8N661	Y2H Array	32296183
Intra	GUCA2A	Q02747	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	GUCA2A	Q02747	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	GUCA2A	Q02747	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	GUCA2A	Q02747	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	GUCA2A	Q02747	GOLM1	Homo sapiens	Q8NBJ4	Y2H Prey Pooling	32296183
Intra	GUCA2A	Q02747	GOLM1	Homo sapiens	Q8NBJ4	Validated Y2H	32296183
Intra	GUCA2A	Q02747	GOLM1	Homo sapiens	Q8NBJ4	Y2H Array	32296183
Intra	GUCA2A	Q02747	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	GUCA2A	Q02747	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	GUCA2A	Q02747	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	GUCA2A	Q02747	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Large Intestine Adenoma	Adenoma Of Large Intestine
Secretory Diarrhea
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Anismus
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Osmotic Diarrhea
Acromesomelic Dysplasia	Acromesomelic Dwarfism Dysplasia, Acromesomelic Acromesomelic Dysplasia Hunter-Thompson Type
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Leber Congenital Amaurosis 1	LCA1 Amaurosis Congenita Of Leber I Lca Retinal Blindness, Congenital Crb Leber Congenital Amaurosis Type I Leber Congenital Amaurosis, Type 1 Amaurosis Congenita Of Leber, Type 1
Constipation
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS05916	GUCA2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GUCA2A	VGNC	VGNC:29716
Mus musculus	GUCA2A	MGD	MGI:102738
Macaca mulatta	GUCA2A	VGNC	VGNC:73325
Canis familiaris	GUCA2A	VGNC	VGNC:41564
Felis catus	GUCA2A	VGNC	VGNC:67512
Rattus norvegicus	GUCA2A	RGD	RGD:2766
Others	GUCA2A	NCBI