KRT10 - keratin 10 Gene
Also Known as BIE; EHK; IHL; K10; KPP; BCIE; CK10
Species: Homo sapiens
About KRT10
This gene has 2 transcripts (splice variants), 104 orthologues, 68 paralogues and is associated with 9 phenotypes. Restricted expression toward skin (RPKM 7171.9).
Summary
This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the Cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008]
KRT10 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_000421.5 | NP_000412.4 | keratin, type I cytoskeletal 10 isoform 1 |
| NM_001379366.1 | NP_001366295.1 | keratin, type I cytoskeletal 10 isoform 2 |
| Molecular Function GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
19627498 | GOA |
| enables protein heterodimerization activity |
IDA
IDA: Inferred from direct assay
|
27595935 | GOA |
| enables structural constituent of skin epidermis |
IDA
IDA: Inferred from direct assay
|
7543090 | GOA |
| Biological Process GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| involved in keratinocyte differentiation |
IEP
IEP: Inferred from expression pattern
|
22170488 | GOA |
| involved in peptide cross-linking |
IDA
IDA: Inferred from direct assay
|
7543090 | GOA |
| involved in protein heterotetramerization |
IDA
IDA: Inferred from direct assay
|
27595935 | GOA |
| Cellular Component GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| located in cornified envelope |
IDA
IDA: Inferred from direct assay
|
7543090 | GOA |
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
22170488 | GOA |
| located in keratin filament |
IPI
IPI: Inferred from physical interaction
|
27595935 | GOA |
KRT10 Protein Structure
Filament: Intermediate filament protein (145 - 458)
- 0
- 100
- 200
- 300
- 400
- 500
- 584 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
keratin, type I cytoskeletal 10 |
|
KRT10 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Verweise |
|---|---|---|---|---|---|---|---|
|
Intra
|
KRT10 | P13645 | KRT1 | Homo sapiens | P04264 | 27595935 | |
|
Intra
|
KRT10 | P13645 | KRT1 | Homo sapiens | P04264 | 27595935 | |
|
Intra
|
KRT10 | P13645 | KRT1 | Homo sapiens | P04264 | 27595935 | |
|
Intra
|
KRT10 | P13645 | KRT1 | Homo sapiens | P04264 | 27595935 |
KRT10 Antibodies
| Art. -Nr. | Produktname | Anwendung | Reactivity |
|---|---|---|---|
| HY-P82112 | Cytokeratin 10 Antibody (YA1857) | WB, IHC-P | Human, Hamster, Mouse, Rat |
| HY-P82112A | Cytokeratin 10 Antibody (YA1857)(PBS only) | WB, IHC-P | Human, Hamster, Mouse, Rat |
| HY-P84087 | Cytokeratin 10 Antibody (YA3784) | WB, IHC-P, FC, ELISA | Human, Mouse, Monkey, Rat |
| HY-P84087A | Cytokeratin 10 Antibody (YA3784)(PBS only) | WB, IHC-P, FC, ELISA | Human, Mouse, Monkey, Rat |
| HY-P85938 | Cytokeratin Antibody (YA5630) | IHC-P, WB, ICC/IF, ELISA | Human, Mouse, Rat |
| HY-P86026 | Cytokeratin Antibody (YA5718) | IHC-P, ELISA | Human, Mouse, Rat |
| HY-P86031 | Cytokeratin 10 Antibody (YA5723) | IHC-P, ICC/IF, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Ichthyosis, Cyclic, With Epidermolytic Hyperkeratosis |
|
|
| Ichthyosis With Confetti |
|
|
| Epidermolytic Hyperkeratosis |
|
|
| Autosomal Recessive Epidermolytic Ichthyosis |
|
|
| Autosomal Dominant Epidermolytic Ichthyosis |
|
|
| Epidermolytic Acanthoma |
|
|
| Keratosis |
|
|
| Steatocystoma Multiplex |
|
|
| Acanthoma |
|
|
| Ichthyosis |
|
|
| Epidermolysis Bullosa Simplex |
|
|
| Keratoacanthoma |
|
|
| Bowen'S Disease |
|
|
| Papilloma |
|
|
| Mucinous Tubular And Spindle Renal Cell Carcinoma |
|
|
| Lichen Planus |
|
|
| Large Cell Acanthoma |
|
|
| Ichthyosis Bullosa Of Siemens |
|
|
| Skin Disease |
|
|
| Cholesteatoma Of Middle Ear |
|
|
| Palmoplantar Keratosis |
|
|
| Clear Cell Acanthoma |
|
|
| Epidermolysis Bullosa |
|
|
| Borst-Jadassohn Intraepidermal Carcinoma |
|
|
| Psoriasis |
|
|
| Hidradenitis Suppurativa |
|
|
| Endocarditis |
|
|
| Keratosis, Seborrheic |
|
|
| Nevus, Epidermal |
|
|
| Palmoplantar Keratoderma, Epidermolytic |
|
|
| Nodular Hidradenoma |
|
|
| Pulmonary Artery Leiomyosarcoma |
|
|
| Pachyonychia Congenita 1 |
|
|
| Eccrine Papillary Adenoma |
|
|
| Trichothiodystrophy 1, Photosensitive |
|
|
| Skin Papilloma |
|
|
| Vohwinkel Syndrome |
|
|
| Eccrine Sweat Gland Neoplasm |
|
|
| Ectodermal Dysplasia 9, Hair/Nail Type |
|
|
| Malignant Biphasic Mesothelioma |
|
|
| Clear Cell Hidradenoma |
|
|
| Ichthyosis Vulgaris |
|
|
| Toxicodendron Dermatitis |
|
|
| Eccrine Acrospiroma |
|
|
| Actinic Keratosis |
|
|
| Erythrokeratodermia Variabilis Et Progressiva 1 |
|
|
| Ichthyosis, Congenital, Autosomal Recessive 4b |
|
|
| Basal Cell Carcinoma |
|
|
| Epidermolysis Bullosa Simplex 1a, Generalized Severe |
|
|
| Cervical Squamous Cell Carcinoma |
|
|
| Hair Follicle Neoplasm |
|
|
| Benign Chronic Pemphigus |
|
|
| Autosomal Recessive Congenital Ichthyosis |
|
|
| Skin Squamous Cell Carcinoma |
|
|
| Epidermolysis Bullosa Simplex Localized Type |
|
|
| Porokeratosis |
|
|
| Junctional Epidermolysis Bullosa |
|
|
| Recessive Dystrophic Epidermolysis Bullosa |
|
|
| Integumentary System Disease |
|
|
| Tibial Adamantinoma |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | KRT10 | MGD | MGI:96685 |
| Canis familiaris | KRT10 | VGNC | VGNC:42516 |
| Bos taurus | KRT10 | VGNC | VGNC:30717 |
| Rattus norvegicus | KRT10 | RGD | RGD:1359092 |
| Macaca mulatta | KRT10 | VGNC | VGNC:74207 |
| Felis catus | KRT10 | VGNC | VGNC:67983 |
| Others | KRT10 | NCBI |