COPS4 - COP9 signalosome subunit 4 Gene

Also Known as CSN4; SGN4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51138

About COPS4

Cytogenetic location: 4q21.22 Genomic coordinates (GRCh38): 4:83,035,183-83,075,818 (from NCBI)

This gene has 11 transcripts (splice variants), 207 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 26.4), brain (RPKM 21.8) and 25 other tissues.

Summary

This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S Proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

COPS4 Products (3)

mRNA	Protein	Name
NM_001258006.2	NP_001244935.1	COP9 signalosome complex subunit 4 isoform 2
NM_001330727.2	NP_001317656.1	COP9 signalosome complex subunit 4 isoform 3
NM_016129.3	NP_057213.2	COP9 signalosome complex subunit 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in protein deneddylation	IDA IDA: Inferred from direct assay	19141280	GOA
involved in protein deneddylation	IMP IMP: Inferred from mutant phenotype	21102408	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of COP9 signalosome	IDA IDA: Inferred from direct assay	18850735	GOA
part of COP9 signalosome	IPI IPI: Inferred from physical interaction	25043011	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	24421388	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24421388	GOA
located in synaptic vesicle	IDA IDA: Inferred from direct assay	21102408	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COPS4 Protein Structure

PCI

0
100
200
300
406 a.a.

Protein Preferred Names	Protein Names
COP9 signalosome complex subunit 4	COP9 constitutive photomorphogenic homolog subunit 4

COPS4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	COPS4	Q9BT78	PCDHB12	Homo sapiens	Q9Y5F1	Validated Y2H	32296183
Intra	COPS4	Q9BT78	STK11	Homo sapiens	Q15831	Anti Tag CoIP	25852190
Intra	COPS4	Q9BT78	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	26871637
Intra	COPS4	Q9BT78	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	25416956
Intra	COPS4	Q9BT78	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	26871637
Intra	COPS4	Q9BT78	USHBP1	Homo sapiens	Q8N6Y0	Y2H Pooling	16189514
Intra	COPS4	Q9BT78	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	26871637
Intra	COPS4	Q9BT78	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	25416956
Intra	COPS4	Q9BT78	BRME1	Homo sapiens	Q0VDD7	Y2H Pooling	16189514
Intra	COPS4	Q9BT78	BRME1	Homo sapiens	Q0VDD7	Pull Down	16189514
Intra	COPS4	Q9BT78	KRT19	Homo sapiens	P08727	Validated Y2H	26871637
Intra	COPS4	Q9BT78	KRT19	Homo sapiens	P08727	Y2H Array	26871637
Intra	COPS4	Q9BT78	KRT19	Homo sapiens	P08727	Y2H Prey Pooling	26871637
Intra	COPS4	Q9BT78	FOS	Homo sapiens	P01100	Display Tech	20195357
Intra	COPS4	Q9BT78	FOS	Homo sapiens	P01100	TAP	20195357

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Xeroderma Pigmentosum, Complementation Group E	Xeroderma Pigmentosum V Xp5 Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype Xpe Xp, Group E Xeroderma Pigmentosum, Type 5 Xeroderma Pigmentosum Complementation Group E XP-E Xp Group E
Sulfonamide Allergy
Cockayne Syndrome	Cockayne'S Syndrome Dwarfism-Retinal Atrophy-Deafness Syndrome Neill-Dingwall Syndrome Progeria-Like Syndrome Progeroid Nanism Cs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS03029	COPS4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	COPS4	RGD	RGD:1302952
Canis familiaris	COPS4	VGNC	VGNC:39511
Felis catus	COPS4	VGNC	VGNC:61089
Bos taurus	COPS4	VGNC	VGNC:27601
Macaca mulatta	COPS4	VGNC	VGNC:71183
Mus musculus	COPS4	MGD	MGI:1349414
Others	COPS4	NCBI