Tacstd2 - tumor-associated calcium signal transducer 2 Gene

Also Known as Ly97; EGP-1; TROP2; GA733-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 56753

Summary

Involved in several processes, including negative regulation of branching involved in ureteric bud morphogenesis; negative regulation of cellular component organization; and negative regulation of substrate adhesion-dependent cell spreading. Acts upstream of or within positive regulation of stem cell differentiation; regulation of epithelial cell proliferation; and ureteric bud morphogenesis. Located in several cellular components, including basal plasma membrane; extracellular space; and lateral plasma membrane. Is expressed in alimentary system; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in corneal dystrophy and gelatinous drop-like corneal dystrophy. Orthologous to human TACSTD2 (tumor associated calcium signal transducer 2). [provided by Alliance of Genome Resources, Apr 2022]

Tacstd2 Products (1)

mRNA	Protein	Name
NM_020047.3	NP_064431.2	tumor-associated calcium signal transducer 2 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Verweise	Source
involved in negative regulation of branching involved in ureteric bud morphogenesis	IDA IDA: Inferred from direct assay	22194864	MGI
involved in negative regulation of cell motility	IDA IDA: Inferred from direct assay	22194864	MGI
involved in negative regulation of epithelial cell migration	IDA IDA: Inferred from direct assay	22194864	MGI
involved in negative regulation of ruffle assembly	IDA IDA: Inferred from direct assay	22194864	MGI
involved in negative regulation of stress fiber assembly	IDA IDA: Inferred from direct assay	22194864	MGI
involved in negative regulation of substrate adhesion-dependent cell spreading	IDA IDA: Inferred from direct assay	22194864	MGI
acts upstream of or within positive regulation of stem cell differentiation	IDA IDA: Inferred from direct assay	23070813	MGI
involved in regulation of epithelial cell proliferation	IEP IEP: Inferred from expression pattern	22194864	MGI
involved in ureteric bud morphogenesis	IEP IEP: Inferred from expression pattern	22194864	MGI

Cellular Component GO Annotation	Evidence	Verweise	Source
located in basal plasma membrane	IDA IDA: Inferred from direct assay	22194864	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	23070813	MGI
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	22194864	MGI
located in membrane	IDA IDA: Inferred from direct assay	23070813	MGI
located in nucleus	IDA IDA: Inferred from direct assay	23070813	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	9462726	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
tumor-associated calcium signal transducer 2	cell surface glycoprotein Trop-2 lymphocyte antigen 97 tunor-associated calcium signal transducer 2

Recombinant Tacstd2 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P71387	TROP-2 Protein, Mouse (HEK293, His)	Q8BGV3 (Q25-G270)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74488	TROP-2 Protein, Mouse (HEK293, hFc)	Q8BGV3 (Q25-G270)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS14152	TACSTD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17390	Tacstd2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23845	Tacstd2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P990827	Anti-TROP-2 Antibody (Pr1E11)	Inhibitor	95.00%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tacstd2	NCBI	NCBI:4070