SDC2 - syndecan 2 Gene

Also Known as HSPG; CD362; HSPG1; SYND2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6383

About SDC2

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:96,493,813-96,611,790 (from NCBI)

This gene has 8 transcripts (splice variants), 228 orthologues and 3 paralogues. Broad expression in thyroid (RPKM 143.2), liver (RPKM 70.5) and 19 other tissues.

Summary

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]

SDC2 Products (1)

mRNA Protein Name
NM_002998.4 NP_002989.2 syndecan-2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
18256285 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
18093920 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9660868 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SDC2 Protein Structure

Syndecan

Syndecan: Syndecan domain (136 - 199)

  • 0
  • 100
  • 201 a.a.
Protein Preferred Names Protein Names

syndecan-2

  • cell surface-associated heparan sulfate proteoglycan 1

SDC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
SDC2 P34741 ESRP1 Homo sapiens Q6NXG1
Y2H Array
32814053
Intra
SDC2 P34741 ESRP1 Homo sapiens Q6NXG1
Y2H Pooling
32814053
Intra
SDC2 P34741 ESRP1 Homo sapiens Q6NXG1
Validated Y2H
32814053
Intra
SDC2 P34741 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
SDC2 P34741 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
SDC2 P34741 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
SDC2 P34741 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra
SDC2 P34741 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra
SDC2 P34741 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra
SDC2 P34741 NF1 Homo sapiens P21359
Y2H
11356864
Intra
SDC2 P34741 SDC1 Homo sapiens P18827
Anti Tag CoIP
33961781
Intra
SDC2 P34741 SDC1 Homo sapiens P18827
Comigration in Gel
18093920
Intra
SDC2 P34741 SDC2 Homo sapiens P34741
Comigration in Gel
18093920
Intra
SDC2 P34741 SDC4 Homo sapiens P31431
Anti Tag CoIP
33961781
Intra
SDC2 P34741 ccsb_13186 Homo sapiens EBI-25834291
Validated Y2H
32814053
Intra
SDC2 P34741 SDC2 Homo sapiens P34741
Y2H
21988832
Intra
SDC2 P34741 SDC4 Homo sapiens P31431
Comigration in Gel
18093920
Intra
SDC2 P34741 SDC2 Homo sapiens P34741
ToxCat
18093920
Intra
SDC2 P34741 ccsb_13186 Homo sapiens EBI-25834291
Y2H Array
32814053
Intra
SDC2 P34741 ASPH Homo sapiens Q12797-6
Validated Y2H
32296183
Intra
SDC2 P34741 ccsb_13186 Homo sapiens EBI-25834291
Y2H Pooling
32814053
Intra
SDC2 P34741 TOM1 Homo sapiens O60784-2
Validated Y2H
32814053
Intra
SDC2 P34741 TOM1 Homo sapiens O60784-2
Y2H Pooling
32814053
Intra
SDC2 P34741 TOM1 Homo sapiens O60784-2
Y2H Array
32814053
Intra
SDC2 P34741 NBL1 Homo sapiens P41271-2
Y2H Array
32814053
Intra
SDC2 P34741 NBL1 Homo sapiens P41271-2
Validated Y2H
32814053
Intra
SDC2 P34741 NBL1 Homo sapiens P41271-2
Y2H Pooling
32814053
Intra
SDC2 P34741 MAPK8IP2 Homo sapiens Q13387-4
Validated Y2H
32814053
Intra
SDC2 P34741 MAPK8IP2 Homo sapiens Q13387-4
Y2H Array
32814053
Intra
SDC2 P34741 MAPK8IP2 Homo sapiens Q13387-4
Y2H Pooling
32814053
Intra
SDC2 P34741 SDC3 Homo sapiens O75056
Comigration in Gel
18093920
Intra
SDC2 P34741 GRN Homo sapiens P28799-2
Y2H Array
32814053
Intra
SDC2 P34741 GRN Homo sapiens P28799-2
Validated Y2H
32814053
Intra
SDC2 P34741 GRN Homo sapiens P28799-2
Y2H Pooling
32814053
Intra
SDC2 P34741 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra
SDC2 P34741 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra
SDC2 P34741 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra
SDC2 P34741 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
SDC2 P34741 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
SDC2 P34741 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
SDC2 P34741 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
SDC2 P34741 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
SDC2 P34741 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
SDC2 P34741 GRN Homo sapiens P28799
Y2H Array
32814053
Intra
SDC2 P34741 GRN Homo sapiens P28799
Validated Y2H
32814053
Intra
SDC2 P34741 GRN Homo sapiens P28799
Y2H Pooling
32814053
Intra
SDC2 P34741 PIK3R1 Homo sapiens P27986-2
Validated Y2H
32814053
Intra
SDC2 P34741 PIK3R1 Homo sapiens P27986-2
Y2H Array
32814053
Intra
SDC2 P34741 PIK3R1 Homo sapiens P27986-2
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SDC2 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P70995 Syndecan-2 Protein, Human (HEK293, His) AAH49836.1 (E19-E144) ≥ 95%, as determined by reducing SDS-PAGE.

SDC2 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P811161 Syndecan 2 Antibody WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Kaposi Sarcoma

  • Kaposi'S Sarcoma

  • Kaposi Sarcoma, Susceptibility To

  • Kaposi'S Sarcoma Of Lung

  • Kaposi'S Sarcoma Of Palate

  • Kaposi'S Sarcoma Of Soft Tissue

  • Kaposi'S Sarcoma-Associated Herpesvirus

  • Multiple Idiopathic Pigmented Hemangiosarcoma

  • Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To

  • African Lymphadenopathic Kaposi'S Sarcoma

  • Anal Kaposi'S Sarcoma

  • Cardiac Kaposi'S Sarcoma

  • Central Nervous System Kaposi'S Sarcoma

  • Conjunctival Kaposi'S Sarcoma

  • Corneal Kaposi'S Sarcoma

  • Cutaneous Kaposi'S Sarcoma

  • Esophageal Kaposi'S Sarcoma

  • Gallbladder Kaposi'S Sarcoma

  • Gastric Kaposi'S Sarcoma

  • Intestinal Kaposi'S Sarcoma

  • Kaposi'S Sarcoma Of Anus

  • Kaposi'S Sarcoma Of Central Nervous System

  • Kaposi'S Sarcoma Of Conjunctiva

  • Kaposi'S Sarcoma Of Cornea

  • Kaposi'S Sarcoma Of Esophagus

  • Kaposi'S Sarcoma Of Gastrointestinal Sites

  • Kaposi'S Sarcoma Of Heart

  • Kaposi'S Sarcoma Of Lymph Nodes

  • Kaposi'S Sarcoma Of Penis

  • Kaposi'S Sarcoma Of Skin

  • Kaposi'S Sarcoma Of Soft Tissues

  • Kaposi'S Sarcoma Of The Cns

  • Kaposi'S Sarcoma Of The Gallbladder

  • Kaposi'S Sarcoma Of The Prostate

  • Kaposi'S Sarcoma, Lung

  • Kaposi'S Sarcoma, Skin

  • Lymph Node Kaposi'S Sarcoma

  • Lymphadenopathic Kaposi'S Sarcoma

  • Palate Kaposi'S Sarcoma

  • Penis Kaposi'S Sarcoma

  • Prostate Kaposi'S Sarcoma

  • Pulmonary Kaposi'S Sarcoma

  • Soft Tissue Kaposi'S Sarcoma

  • Hhv8

  • Human Herpesvirus 8

  • Kshv

  • Kaposi Sarcoma Herpesvirus

  • Mediterranean Kaposi Sarcoma

  • Non Aids Related Kaposi Sarcoma

  • Sarcoma, Kaposi

  • Sarcoma, Kaposi, Susceptibility To

  • Non-Aids-Related Kaposi Sarcoma

  • Angiolymphoid Hyperplasia

  • Angiofollicular Ganglionic Hyperplasia

  • Multi-Centric Castleman'S Disease
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS12580 SDC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18048 Sdc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24522 Sdc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SDC2 VGNC VGNC:54120
Mus musculus SDC2 MGD MGI:1349165
Macaca mulatta SDC2 VGNC VGNC:76998
Felis catus SDC2 VGNC VGNC:64944
Bos taurus SDC2 VGNC VGNC:34379
Rattus norvegicus SDC2 RGD RGD:3649
Others SDC2 NCBI