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BPI - bactericidal permeability increasing protein Gene

Also Known as rBPI; BPIFD1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 671

About BPI

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:38,304,156-38,337,505 (from NCBI)

This gene has 6 transcripts (splice variants), 123 orthologues and 12 paralogues. Restricted expression toward bone marrow (RPKM 549.1).

Summary

This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014]

BPI Products (1)

mRNA	Protein	Name
NM_001725.3	NP_001716.3	bactericidal permeability-increasing protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables lipopolysaccharide binding	IDA IDA: Inferred from direct assay	8409400	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in antibacterial humoral response	IDA IDA: Inferred from direct assay	1937776	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	1937776	GOA
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	1937776	GOA
involved in defense response to Gram-negative bacterium	IDA IDA: Inferred from direct assay	1937776	GOA
involved in negative regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	8409400	GOA
involved in negative regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	8409400	GOA
involved in negative regulation of macrophage activation	IDA IDA: Inferred from direct assay	8409400	GOA
involved in negative regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	8409400	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	1937776	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BPI Protein Structure

LBP_BPI_CETP

LBP_BPI_CETP_C

0
100
200
300
400
487 a.a.

Protein Preferred Names	Protein Names
bactericidal permeability-increasing protein	BPI fold containing family D, member 1

Recombinant BPI Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P7644	BPI Protein, Human (HEK293, His)	AAH40955.1 (V32-K487)	≥ 95%, as determined by reducing SDS-PAGE.

BPI Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P83323	BPI Antibody (YA3068)	WB, ICC/IF, FC	Human

Related Diseases

Diseases	Alias
Meningococcemia
Reactive Arthritis	Postdysenteric Arthropathy Reiter Disease Pira Reiter Syndrome Reiters Syndrome Arthritis, Reactive Fiessinger Leroy Reiter Syndrome Post-Bacterial Arthropathy Reiter'S Disease Post-Infectious Arthritis Post-Infectious Reactive Arthropathy Reiter'S Syndrome Arthritis Urethritica Fiessinger-Leroy Disease Polyarthritis Enterica Venereal Arthritis Arthritis Reactive Post-Dysenteric Arthropathy Arthritis, Venereal
Vasculitis	Angiitis Autoimmune Vasculitis Systemic Vasculitis Vasculitis, Autoimmune
Bronchiectasis	Polynesian Bronchiectasis Kartagener Syndrome Bronchiectasis Nos
Cholangitis, Primary Sclerosing	Primary Sclerosing Cholangitis PSC Sclerosing Cholangitis Cholangitis, Sclerosing Cholangitis Primary Sclerosing Psc - [Primary Sclerosing Cholangitis]
Dacryocystitis	Nasolacrimal Sac Infection
Acute Inflammation Of Lacrimal Passage
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Granulomatosis With Polyangiitis	GPA Wegener Granulomatosis Wegener Granulomatosis, Formerly Midline Granulomatosis Wg, Formerly Necrotizing Respiratory Granulomatosis Wg Wegeners Granulomatosis Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis
Toxic Shock Syndrome	Septic Shock Toxic Shock Tss Shock, Septic Staphylococcal Toxic Shock Syndrome Tss - [Toxic Shock Syndrome]
Alpha-1-Antitrypsin Deficiency	Alpha 1-Antitrypsin Deficiency Alpha-1 Antitrypsin Deficiency Aat Deficiency Aatd A1ATD Emphysema Due To Aat Deficiency A1at Deficiency Emphysema-Cirrhosis, Due To Aat Deficiency Hemorrhagic Diathesis Due To Antithrombin Pittsburgh Alpha-1 Antiprotease Deficiency Alpha 1 Antitrypsin Deficiency Aat Alpha-1 Protease Inhibitor Deficiency Alpha-1 Related Emphysema Genetic Emphysema Hereditary Pulmonary Emphysema Inherited Emphysema Alpha-1-Proteinase Inhibitor Deficiency Alpha1-Antitrypsin Deficiency Alpha-1-Antitrypsin Deficiency, Autosomal Recessive Emphysema, Hereditary Pulmonary Aatd - [Alpha-1-Antitrypsin] Deficiency
Mastitis	Breast Inflammation Inflammatory Breast Disease Inflammatory Disease Of Breast Inflammation Of Non-Human Mammary Gland Inflammatory Disorder Of Breast Mastitis Nos Acute Mastitis Nos Acute Nonpuerperal Mastitis Nonpuerperal Mastitis Nos Subacute Mastitis Nos
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Bacteremia 2	Bacteremia Bacteremia, Susceptibility To, 2 BACTS2 Bacteremia, Susceptibility To Bacteremia, Susceptibility To, Type 2
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-15164A	Icotinib	Inhibitor	99.96%	Yes
HY-15164	Icotinib Hydrochloride	Inhibitor	99.89%	Yes

Clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-109189A	Rezivertinib hydrochloride	Inhibitor	/	Phase 3
HY-114356	BPI-9016M	Inhibitor	97.13%	Phase 1
HY-164464	BPI-15086	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (11)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-109189	Rezivertinib	Inhibitor	99.62%	Unkown
HY-141703A	DC-BPi-11 hydrochloride	Inhibitor	97.36%	Unkown
HY-150211	DC-BPi-03	Inhibitor	99.77%	Unkown
HY-156646	Tibremciclib	Inhibitor	/	Unkown
HY-141703	DC-BPi-11	Inhibitor	/	Unkown
HY-15164AS	Icotinib-d4		/	Unkown
HY-173165	OA-Br-1		/	Unkown
HY-178697	DC-BPi-07	Inhibitor	/	Unkown
HY-RS01580	BPI Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18324	Bpi Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24802	Bpi Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BPI	RGD	RGD:1303179
Mus musculus	BPI	MGD	MGI:3045315
Canis familiaris	BPI	VGNC	VGNC:49649
Felis catus	BPI	VGNC	VGNC:60152
Bos taurus	BPI	VGNC	VGNC:97246
Macaca mulatta	BPI	VGNC	VGNC:70277
Others	BPI	NCBI