TGM2 - transglutaminase 2 Gene

Also Known as TGC; tTG; G(h); hTG2; TG(C)

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7052

About TGM2

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:38,127,385-38,168,475 (from NCBI)

This gene has 6 transcripts (splice variants), 244 orthologues and 8 paralogues. Broad expression in placenta (RPKM 177.0), endometrium (RPKM 107.6) and 16 other tissues.

Summary

Transglutaminases are Enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in Apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

TGM2 Products (5)

mRNA	Protein	Name
NM_001323316.2	NP_001310245.1	protein-glutamine gamma-glutamyltransferase 2 isoform a
NM_001323317.2	NP_001310246.1	protein-glutamine gamma-glutamyltransferase 2 isoform c
NM_001323318.2	NP_001310247.1	protein-glutamine gamma-glutamyltransferase 2 isoform d
NM_004613.4	NP_004604.2	protein-glutamine gamma-glutamyltransferase 2 isoform a
NM_198951.3	NP_945189.1	protein-glutamine gamma-glutamyltransferase 2 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables GTP binding	IDA IDA: Inferred from direct assay	7649299	GOA
enables calcium ion binding	IDA IDA: Inferred from direct assay	23941696	GOA
enables histone dopaminyltransferase activity	IDA IDA: Inferred from direct assay	32273471	GOA
enables histone serotonyltransferase activity	IDA IDA: Inferred from direct assay	30867594	GOA
enables peptide histaminyltransferase activity	IDA IDA: Inferred from direct assay	23797785	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9442029	GOA
enables protein-glutamine gamma-glutamyltransferase activity	IDA IDA: Inferred from direct assay	7649299	GOA
enables protein-glutamine gamma-glutamyltransferase activity	IMP IMP: Inferred from mutant phenotype	7592956	GOA
enables protein-glutamine glutaminase activity	IDA IDA: Inferred from direct assay	9623982	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in apoptotic cell clearance	IDA IDA: Inferred from direct assay	19628791	GOA
involved in cellular response to cocaine	IDA IDA: Inferred from direct assay	32273471	GOA
involved in cellular response to dopamine	IDA IDA: Inferred from direct assay	32273471	GOA
involved in cellular response to serotonin	IDA IDA: Inferred from direct assay	30867594	GOA
acts upstream of positive effect dopamine secretion	IDA IDA: Inferred from direct assay	32273471	GOA
acts upstream of positive effect gene expression	IDA IDA: Inferred from direct assay	30867594	GOA
involved in negative regulation of endoplasmic reticulum calcium ion concentration	IMP IMP: Inferred from mutant phenotype	24349085	GOA
involved in peptide cross-linking	IDA IDA: Inferred from direct assay	9252372	GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	7592956	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	17116873	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	24349085	GOA
involved in positive regulation of mitochondrial calcium ion concentration	IMP IMP: Inferred from mutant phenotype	24349085	GOA
involved in positive regulation of neurogenesis	IDA IDA: Inferred from direct assay	30867594	GOA
involved in positive regulation of sprouting angiogenesis	IDA IDA: Inferred from direct assay	28198360	GOA
involved in protein deamination	IDA IDA: Inferred from direct assay	9623982	GOA
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	17116873	GOA
involved in regulation of apoptotic cell clearance	IDA IDA: Inferred from direct assay	7935379	GOA
involved in regulation of apoptotic process	IDA IDA: Inferred from direct assay	9252372	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in chromatin	IDA IDA: Inferred from direct assay	9575137	GOA
located in cytosol	IDA IDA: Inferred from direct assay	9575137	GOA
located in extracellular matrix	IDA IDA: Inferred from direct assay	12506096	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	24349085	GOA
part of nucleosome	IDA IDA: Inferred from direct assay	30867594	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9575137	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	17116873	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	2578891	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	8105889	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TGM2 Protein Structure

Transglut_N

Transglut_core

Transglut_C

0
200
400
600
687 a.a.

Protein Preferred Names	Protein Names
protein-glutamine gamma-glutamyltransferase 2	C polypeptide, protein-glutamine-gamma-glutamyltransferase

TGM2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	TGM2	P21980	FN1	Homo sapiens	P02751	Anti Tag CoIP	33961781
Intra	TGM2	P21980	FN1	Homo sapiens	P02751	Pull Down	20080707
Intra	TGM2	P21980	FN1	Homo sapiens	P02751	Enzymatic Study	22442151
Intra	TGM2	P21980	AKAP13	Homo sapiens	Q12802	Confocal	16301118
Intra	TGM2	P21980	P39060-PRO_0000005794	Homo sapiens	P39060-PRO_0000005794	SPR Array	19542224
Intra	TGM2	P21980	VHL	Homo sapiens	P40337	Anti Bait CoIP	21625219
Intra	TGM2	P21980	VHL	Homo sapiens	P40337	Enzymatic Study	21625219
Intra	TGM2	P21980	RELA	Homo sapiens	Q04206	Confocal	16951195
Intra	TGM2	P21980	RELA	Homo sapiens	Q04206	Anti Bait CoIP	16951195
Intra	TGM2	P21980	KRT19	Homo sapiens	P08727	Anti Tag CoIP	20080707
Intra	TGM2	P21980	P05067-PRO_0000000092	Homo sapiens	P05067-PRO_0000000092	SPR Array	19542224

Cross: Cross-species interaction Intra: Intraspecies interaction

TGM2 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P82510	Transglutaminase 2 Antibody (YA2255)	WB, IHC-P, IP	Human, Mouse, Rat
HY-P82510A	Transglutaminase 2 Antibody (YA2255)(PBS only)	WB, IHC-P, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Dermatitis Herpetiformis	Duhring'S Disease Duhring-Brocq Disease Dermatosis Herpetiformis Brocq-Duhring Disease Dh Duhring Brocq Disease Dh - [Dermatitis Herpetiformis]
Balanitis Xerotica Obliterans	Penile Lichen Sclerosus Penile Leukoplakia
Balanitis
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome
Tropical Sprue	Tropical Steatorrhea Tropical Enteropathy Sprue, Tropical Sprue - Tropical Idiopathic Tropical Malabsorption Syndrome Tropical Steatorrhoea Tropical Diarrhoea Ts - [Tropical Sprue] Psilosis Sprue Nos
Huntington Disease	Huntington'S Disease Huntington Chorea Huntington'S Chorea HD Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Pancreatic Ductal Carcinoma	Carcinoma, Pancreatic Ductal Malignant Neoplasm Of Duct Of Wirsung Pancreatic Duct Cancer Carcinoma Pancreatic Ductal
Wheat Allergy	Wheat Allergic Reaction Wheat Hypersensitivity Allergy To Wheat Allergy Wheat
Myositis	Idiopathic Inflammatory Myopathy Idiopathic Inflammatory Myositis Iim Imm Idiopathic Inflammatory Myopathies Myopathy, Familial Idiopathic Inflammatory Inflammatory Disorder Of Muscle Idiopathic Inflammatory Myopathy, Familial Inflammatory Myopathy, Idiopathic Myopathies Idiopathic Inflammatory Familial Idiopathic Inflammatory Myopathy
Autoimmune Disease Of Gastrointestinal Tract
Jejunoileitis
Microscopic Colitis	Colitis, Microscopic
Lymphocytic Colitis	Colitis, Lymphocytic
Irritable Bowel Syndrome	Irritable Colon Psychogenic Ibs Ibs - [Irritable Bowel Syndrome] Spastic Bowel Syndrome
Immunoglobulin Alpha Deficiency	Iga Deficiency Gamma-A-Globulin Deficiency Immunoglobulin A Deficiency
Gluten Allergy	Allergy To Gluten Gluten Allergic Reaction
Lymphocytic Gastritis
Duodenitis	Hemorrhagic Duodenitis Acute Enteritis Of The Mouse Intestinal Tract Nonspecific Duodenitis Inflammation Of Duodenum Dodecadactylitis Duodenal Inflammation Peptic Duodenitis
Collagenous Colitis	Colitis, Collagenous Microscopic Colitis, Collagenous Type
Pulmonary Hemosiderosis	Idiopathic Pulmonary Hemosiderosis Alveolar Hypoventilation Syndrome Brown Induration Brown Lung Siderosis Hemosiderosis, Pulmonary, With Deficiency Of Gamma-A Globulin Byssinosis
Whipple Disease	Intestinal Lipodystrophy Whipple'S Disease Intestinal Lipophagic Granulomatosis Secondary Non-Tropical Sprue Tropheryma Whippelii Infection Whipples Disease
Aspirin Allergy	Acetylsalicylic Acid Allergy Asa Allergy
Lactose Intolerance	Lactose Malabsorption Lm - Lactose Malabsorption Alactasia Dairy Product Intolerance Hypolactasia Milk Sugar Intolerance Cow Milk Enteropathy Intolerance Or Malabsorption Of Lactose Lm - [Lactose Malabsorption] Milk Intolerance
Spinocerebellar Ataxia 35	Spinocerebellar Ataxia Type 35 SCA35 Ataxia, Spinocerebellar, Type 35
Oculopharyngeal Muscular Dystrophy	OPMD Muscular Dystrophy, Oculopharyngeal Dystrophy, Oculopharyngeal Muscular Oculopharyngeal Dystrophy Progressive Muscular Dystrophy, Oculopharyngeal Type Muscular Dystrophy Oculopharyngeal Dystrophy, Muscular, Oculopharyngeal
Giardiasis	Beaver Feaver Infection By Giardia Lamblia Lambliasis Giardia Lamblia Dysentery Giardial Diarrhoea Lamblia Dysentery Giardia Duodenalis Dysentery Giardia Intestinalis Dysentery
Diarrhea	Diarrhoea Diarrhea Of Presumed Infectious Origin
Chylomicron Retention Disease	CMRD Anderson Disease Lipid Transport Defect Of Intestine Hypobetalipoproteinemia With Accumulation Of Apolipoprotein B-Like Protein In Intestinal Cells Andd Anderson Syndrome Crd Andersons Disease Malabsorption Syndrome
Immunoglobulin A Deficiency 1	Immunoglobulin A Deficiency Selective Iga Deficiency Disease Selective Immunoglobulin A Deficiency IGAD1 Immunoglobulin A, Selective Deficiency Of Iga, Selective Deficiency Of Gamma-A-Globulin, Selective Deficiency Of Selective Iga Immunodeficiency Selective Iga Deficiency Iga Deficiency Selective
Bullous Skin Disease	Skin Diseases Bullous Skin Diseases, Bullous
Ichthyosis	Ichthyoses Non-Syndromic Ichthyosis Congenital Ichthyosis
B Cell Deficiency	Immunoglobulin Heavy Chain Deficiency B Cell Deficiencies Immunoglobulin Heavy Chain Deletion Humoral Immune Defect
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Polymicrogyria, Bilateral Frontoparietal	Bilateral Frontoparietal Polymicrogyria BFPP Cerebellar Ataxia With Neuronal Migration Defect
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Protein-Losing Enteropathy	Protein-Losing Enteropathies Enteropathy, Exudative Exudative Enteropathy Ple - [Protein-Losing Enteropathy]
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Macular Degeneration, Age-Related, 4	Age Related Macular Degeneration 4 ARMD4 Macular Degeneration, Age-Related, Type 4
Autoimmune Disease Of Endocrine System
Dystonia 25	DYT25 Dystonia-25 Dystonia, Type 25
Torsion Dystonia 2	Dystonia 2, Torsion, Autosomal Recessive
Ciliary Dyskinesia, Primary, 5	Primary Ciliary Dyskinesia 5 CILD5 Ciliary Dyskinesia, Primary, 5, Without Situs Inversus Primary Ciliary Dyskinesia 5 Without Situs Inversus Ics5 Immotile Cilia Syndrome 5 Primary Ciliary Dyskinesia 5 With Or Without Situs Inversus Dyskinesia, Ciliary, Primary, Type 5
Constipation
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-128595	MT-4	Inhibitor	99.84%	Unkown
HY-177133	Suvigletistat	Inhibitor	99.82%	Unkown
HY-181732	PROTAC TG2 Degrader-3	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TGM2	MGD	MGI:98731
Rattus norvegicus	TGM2	RGD	RGD:621081
Canis familiaris	TGM2	VGNC	VGNC:47316
Macaca mulatta	TGM2	VGNC	VGNC:78340
Felis catus	TGM2	VGNC	VGNC:66142
Bos taurus	TGM2	VGNC	VGNC:35810
Others	TGM2	NCBI