ACTR5 - actin related protein 5 Gene

Also Known as Arp5; INO80M

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79913

About ACTR5

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:38,748,460-38,772,520 (from NCBI)

This gene has 1 transcript (splice variant), 196 orthologues and 26 paralogues. Ubiquitous expression in testis (RPKM 7.1), lymph node (RPKM 4.1) and 25 other tissues.

Summary

Involved in UV-damage excision repair and double-strand break repair. Located in cytoplasm and nucleus. Part of Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]

ACTR5 Products (1)

mRNA	Protein	Name
NM_024855.4	NP_079131.3	actin-related protein 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16230350	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in UV-damage excision repair	IMP IMP: Inferred from mutant phenotype	20855601	GOA
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	21303910	GOA
involved in double-strand break repair	IMP IMP: Inferred from mutant phenotype	19014934	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	27641337	GOA
involved in regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	25016522	GOA
involved in regulation of DNA strand elongation	IMP IMP: Inferred from mutant phenotype	25016522	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	26340092	GOA
involved in regulation of chromosome organization	IMP IMP: Inferred from mutant phenotype	26340092	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of Ino80 complex	IDA IDA: Inferred from direct assay	18026119	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19014934	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18026119	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACTR5 Protein Structure

Actin

0
100
200
300
400
500
607 a.a.

Protein Preferred Names	Protein Names
actin-related protein 5	ARP5 actin related protein 5 homolog

ACTR5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	ACTR5	Q9H9F9	DDB1	Homo sapiens	Q16531	Anti Bait CoIP	20855601
Intra	ACTR5	Q9H9F9	DDB1	Homo sapiens	Q16531	Pull Down	20855601
Intra	ACTR5	Q9H9F9	DDB1	Homo sapiens	Q16531	Anti Tag CoIP	20855601
Intra	ACTR5	Q9H9F9	PPL	Homo sapiens	O60437	Y2H Prey Pooling	32296183
Intra	ACTR5	Q9H9F9	INO80C	Homo sapiens	Q6PI98	Anti Tag CoIP	26496610
Intra	ACTR5	Q9H9F9	INO80C	Homo sapiens	Q6PI98	Anti Tag CoIP	35271311
Intra	ACTR5	Q9H9F9	INO80	Homo sapiens	Q9ULG1	Anti Tag CoIP	19014934
Intra	ACTR5	Q9H9F9	INO80	Homo sapiens	Q9ULG1	3D-EM	29643506
Intra	ACTR5	Q9H9F9	INO80	Homo sapiens	Q9ULG1	Anti Bait CoIP	20855601
Intra	ACTR5	Q9H9F9	INO80	Homo sapiens	Q9ULG1	Anti Tag CoIP	26496610
Intra	ACTR5	Q9H9F9	ACTR8	Homo sapiens	Q9H981	Anti Tag CoIP	26496610

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Autosomal Recessive Intellectual Developmental Disorder	Mental Retardation, Autosomal Recessive Autosomal Recessive Mental Retardation Autosomal Recessive Non-Syndromic Mental Retardation Autosomal Recessive Non-Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS00233	ACTR5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ACTR5	VGNC	VGNC:25587
Felis catus	ACTR5	VGNC	VGNC:59558
Mus musculus	ACTR5	MGD	MGI:1924748
Rattus norvegicus	ACTR5	RGD	RGD:1307958
Canis familiaris	ACTR5	VGNC	VGNC:37555
Macaca mulatta	ACTR5	VGNC	VGNC:69405
Others	ACTR5	NCBI