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MAFB - MAF bZIP transcription factor B Gene

Also Known as KRML; MCTO; DURS3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9935

About MAFB

Cytogenetic location: 20q12 Genomic coordinates (GRCh38): 20:40,685,848-40,689,236 (from NCBI)

This gene has 1 transcript (splice variant), 245 orthologues, 6 paralogues and is associated with 52 phenotypes.

Summary

The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns. [provided by RefSeq, Jul 2008]

MAFB Products (1)

mRNA	Protein	Name
NM_005461.5	NP_005452.2	transcription factor MafB

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	20102225	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20102225	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in negative regulation of erythrocyte differentiation	IDA IDA: Inferred from direct assay	8620536	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	27181683	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	23661758	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	27208706	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAFB Protein Structure

Maf_N

bZIP_Maf

0
100
200
300
323 a.a.

Protein Preferred Names	Protein Names
transcription factor MafB	Kreisler maf-related leucine zipper homolog

MAFB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	MAFB	Q9Y5Q3	BACH1	Homo sapiens	O14867	Anti Tag CoIP	33961781
Intra	MAFB	Q9Y5Q3	BACH1	Homo sapiens	O14867	FRET	23661758
Intra	MAFB	Q9Y5Q3	BACH1	Homo sapiens	O14867	Peptide Array	20102225
Intra	MAFB	Q9Y5Q3	IRF3	Homo sapiens	Q14653	Anti Bait CoIP	20581830
Intra	MAFB	Q9Y5Q3	MAF	Homo sapiens	O75444	FRET	23661758
Intra	MAFB	Q9Y5Q3	MAFB	Homo sapiens	Q9Y5Q3	FRET	23661758
Intra	MAFB	Q9Y5Q3	MAFB	Homo sapiens	Q9Y5Q3	Y2H Array	20211142
Intra	MAFB	Q9Y5Q3	MAFB	Homo sapiens	Q9Y5Q3	Peptide Array	20102225
Intra	MAFB	Q9Y5Q3	HBZ	Human T-cell leukemia virus 1	P0C746	Peptide Array	20102225

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Multicentric Carpotarsal Osteolysis Syndrome	Multicentric Carpo-Tarsal Osteolysis With Or Without Nephropathy MCTO Osteolysis, Hereditary, Of Carpal Bones With Or Without Nephropathy Idiopathic Multicentric Osteolysis With Or Without Nephropathy Autosomal Dominant Multicentric Osteolysis Hereditary Osteolysis Of Carpal Bones With Or Without Nephropathy Multicentric Osteolysis, Autosomal Dominant Multicentric Osteolysis Nephropathy Osteolysis, Carpotarsal, Multicentric Syndrome Lytic Lesion
Duane Retraction Syndrome 3 With Or Without Deafness	DURS3 Duane Retraction Syndrome 3 Duane Retraction Syndrome With Congenital Deafness Drs With Deafness Drs With Hearing Loss Durs With Deafness Durs With Hearing Loss Duane Retraction Syndrome With Congenital Hearing Loss
Duane Retraction Syndrome 2	DURS2 Duane Retraction Syndrome, Type 2
Duane Retraction Syndrome	Stilling-Turk-Duane Syndrome Duane'S Syndrome Duane Syndrome Isolated Duane Retraction Syndrome Co-Contractive Retraction Syndrome Duane Anomaly, Isolated Ocular Retraction Syndrome Drs Durs
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Juvenile Rheumatoid Arthritis	Juvenile Idiopathic Arthritis Juvenile Chronic Polyarthritis Monarticular Juvenile Rheumatoid Arthritis Pauciarticular Juvenile Arthritis Still'S Disease Systemic Juvenile Rheumatoid Arthritis Juvenile Chronic Arthritis Acute Juvenile Rheumatoid Arthritis Pauciarticular Onset Juvenile Chronic Arthritis Arthritis, Juvenile Rheumatoid Jia Jra Juvenile Ra Arthritis Juvenile Rheumatoid Stills Disease Juvenile Arthritis Acute Polyarticular Juvenile Rheumatoid Arthritis Pauciarticular Juvenile Rheumatoid Arthritis Rheumatoid Arthritis, Systemic Juvenile
Amblyopia	Lazy Eye
Monoclonal Gammopathy Of Uncertain Significance	Monoclonal Gammopathy Of Undetermined Significance Mgus Mgus - [Monoclonal Gammopathy Of Undetermined Significance] Monoclonal Gammopathy Nos Iga Gammopathy Monoclonal Gammoglobulinopathy
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Smoldering Myeloma
Blood Protein Disease	Blood Protein Disorders Blood Protein Disorder
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate
Plasma Cell Leukemia	Plasma Cell Leukaemia Leukemia, Plasma Cell Plasmacytic Leukaemia Plasmacytic Leukemia Pcl Plasma Cell Leukaemia, Nos Leukemic Plasma Cell Plasma Cell Leukaemia Without Mention Of Remission
Theileriasis	Theileriosis Infection By Theileria
Pancreatic Agenesis	Partial Pancreatic Agenesis Congenital Pancreatic Agenesis Partial Agenesis Of The Pancreas Agenesis, Pancreatic Pancreatic Agenesis, Congenital
Maturity-Onset Diabetes Of The Young	MODY Maturity Onset Diabetes Mellitus In Young Mason-Type Diabetes Mason Type Diabetes Maturity Onset Diabetes Of The Young Mody Syndrome Diabetes Of The Young, Maturity-Onset
Orofacial Cleft	Cleft, Orofacial
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency
Strabismus	Strabismus, Susceptibility To Strabismus, Susceptibility To, 1 Strabismus 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS07959	MAFB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19144	Mafb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25635	Mafb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MAFB	VGNC	VGNC:67982
Canis familiaris	MAFB	VGNC	VGNC:54653
Macaca mulatta	MAFB	VGNC	VGNC:74419
Bos taurus	MAFB	VGNC	VGNC:31139
Rattus norvegicus	MAFB	RGD	RGD:2982
Mus musculus	MAFB	MGD	MGI:104555
Others	MAFB	NCBI