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Art. -Nr.: HY-139226

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GMQ

(Synonyms: 2-Guanidine-4-methylquinazoline)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

GMQ is an acid-sensing ion channel modulator, competitive GABA_AR antagonist. GMQ preferentially, potently, competitively inhibits GABAARs. GMQ inhibits α₁β₂, α₁β₂γ₂, α₄β₂γ₂ and α₅β₂γ₂ GABA_ARs. GMQ enhances neuronal excitation through inhibition of GABAergic transmission. GMQ has anti-histamine effects in the enteric system, inhibiting gastric acid secretion.

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CAS. Nr.: 716-11-0
Formel: C₁₀H₁₁N₅
Molecular Weight:201.23

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

GMQ Chemical Structure

CAS. Nr.: 716-11-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Publications (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	66.41 μM Compound: GNF-Pf-3515	NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)	[PMID: 18579783]
L6	CC₅₀	>64 μM Compound: 20	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 19364854]

Chemical Information

CAS. Nr. 716-11-0
Molecular Weight 201.23
Formel C₁₀H₁₁N₅
SMILES

NC(NC1=NC(C)=C2C=CC=CC2=N1)=N
Synonyms

2-Guanidine-4-methylquinazoline
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

Eur J Pharmacol

2-guanidine-4-methylquinazoline inhibits platelet activation and thrombosis by targeting the acid-sensing ion channel 3. [Abstract]

2026 May 30:1030:179005. PMID: 42219052

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Xiao X, et al. 2-Guanidine-4-methylquinazoline acts as a novel competitive antagonist of A type γ-aminobutyric acid receptors. Neuropharmacology. 2013 Dec;75:126-37. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
Chemical Information
Publications (1)
Reinheit & Dokumentation
Verweise

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GMQ

Publications Citing Use of MedChemExpress (MCE) GMQ