HB43
HB43 is a synthetic amphipathic cationic α-helical peptide, as well as an antibacterial/anticancer peptide. HB43 reduces the number of Methicillin (HY-121544)-resistant Staphylococcus aureus in biofilms in a dose-dependent manner. When loaded into chitosan nanoparticles, it achieves sustained release, and this effect is particularly pronounced under acidic conditions.
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- CAS. Nr.: 932013-61-1
- Formel: C72H129N17O14
- Molecular Weight:1456.90
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
HB43 exhibits anti-cancer activity against MCF-7, SW480, BMKC, H1299, HeLa S3 and PC-3 cells. The LD50 of HB43 for these cells ranges from 6 to 15 μg/mL[1].
HB43 (108-216 μg/mL; 24 h), either free or loaded in P1-CNP, reduces MRSA USA300 LAC biofilm bacterial load and biomass in a dose-dependent manner; P1-CNP-loaded HB43 exhibits superior antibiofilm activity compared to free HB43, with the highest efficacy observed under acidic (pH 5.5) conditions[2].
HB43 (108-216 μg/mL; 24 h) disrupts the membrane integrity of MRSA USA300 LAC biofilm-embedded bacteria in a dose-dependent manner, with the highest membrane damage observed at 216 μg/mL[2].
HB43 (216 μg/mL; 2-4 h) penetrates MRSA USA300 LAC biofilms within 2 h and shows extensive uniform distribution across the biofilm surface by 4 h[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 932013-61-1
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Molecular Weight 1456.90
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Formel C72H129N17O14
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SMILES
N[C@@H](CC1=CC=CC=C1)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
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Sequence
Phe-Ala-Lys-Leu-Leu-Ala-Lys-Leu-Ala-Lys-Lys-Leu-Leu
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Sequence Shortening
FAKLLAKLAKKLL
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Herrera-León C, et al. The impact of phosphatidylserine exposure on cancer cell membranes on the activity of the anticancer peptide HB43. The FEBS journal. 2022 Apr;289(7):1984-2003. [Content Brief]
[2]. Keikhosravani P, et al. Developing antibacterial HB43 peptide-loaded chitosan nanoparticles for biofilm treatment. International journal of biological macromolecules. 2025 May;310(Pt 2):143397. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
HB43 Related Classifications
HY-P12121 Related Classifications
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