Hexane-1,6-diol
Based on 1 publication(s) in Google Scholar
Hexane-1,6-diol is a 6-carbon straight-chain diol with hydroxyl groups at both ends. Hexane-1,6-diol can be used as an additive for drilling fluids. Hexane-1,6-diol can also be used as a substrate in life science-related research.
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- Reinheit: 99.86%
- CAS. Nr.: 629-11-8
- Formel: C6H14O2
- Molecular Weight:118.17
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Hexane-1,6-diol
More
Biologische Aktivität
Hexane-1,6-diol has its monoesters and diesters as substrates for in vitro digestion studies by pancreatic lipase, with hydrolysis and transesterification decomposition pathways[1].
Hexane-1,6-diol is a substrate that can be catalytically lactonized by alcohol dehydrogenases such as AaSDR-1 to produce ε-caprolactone, and its conversion is affected by buffers[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 629-11-8
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Appearance Solid
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Molecular Weight 118.17
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Formel C6H14O2
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Color Colorless to off-white
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SMILES
OCCCCCCO
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Lösungsmittel & Löslichkeit
DMSO : 200 mg/mL (1692.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (42.31 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (42.31 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (267 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Mattson FH, et al. Digestion of the mono- and diesters of hexane-1,6-diol by pancreatic lipase. J Lipid Res. 1972 Mar;13(2):256-62. [Content Brief]
[2]. Dithugoe CD, et al. An Alcohol Dehydrogenase from the Short-Chain Dehydrogenase/Reductase Family of Enzymes for the Lactonization of Hexane-1,6-diol. Chembiochem. 2019 Jan 2;20(1):96-102. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 8.4624 mL | 42.3119 mL | 84.6238 mL | 211.5596 mL |
| 5 mM | 1.6925 mL | 8.4624 mL | 16.9248 mL | 42.3119 mL | |
| 10 mM | 0.8462 mL | 4.2312 mL | 8.4624 mL | 21.1560 mL | |
| 15 mM | 0.5642 mL | 2.8208 mL | 5.6416 mL | 14.1040 mL | |
| 20 mM | 0.4231 mL | 2.1156 mL | 4.2312 mL | 10.5780 mL | |
| 25 mM | 0.3385 mL | 1.6925 mL | 3.3850 mL | 8.4624 mL | |
| 30 mM | 0.2821 mL | 1.4104 mL | 2.8208 mL | 7.0520 mL | |
| 40 mM | 0.2116 mL | 1.0578 mL | 2.1156 mL | 5.2890 mL | |
| 50 mM | 0.1692 mL | 0.8462 mL | 1.6925 mL | 4.2312 mL | |
| 60 mM | 0.1410 mL | 0.7052 mL | 1.4104 mL | 3.5260 mL | |
| 80 mM | 0.1058 mL | 0.5289 mL | 1.0578 mL | 2.6445 mL | |
| 100 mM | 0.0846 mL | 0.4231 mL | 0.8462 mL | 2.1156 mL |
Hexane-1,6-diol Related Classifications
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