Iodofiltic acid

Fischer 344 (female, 10-12 weeks old, 170-200 g)^[1]

8.2 μCi

i.v.

Achieved mean heart radioactivity uptake of 4.62 % injected dose/g at 5 min, 3.63 % injected dose/g at 30 min, 4.26 % injected dose/g at 60 min, and 2.27 % injected dose/g at 4 h.
Reached mean blood radioactivity uptake of 0.71 % injected dose/g at 5 min, 1.60 % injected dose/g at 30 min, 1.70 % injected dose/g at 60 min, and 1.13 % injected dose/g at 4 h.
Attained mean lung radioactivity uptake of 1.45 % injected dose/g at 5 min, 1.15 % injected dose/g at 30 min, 1.21 % injected dose/g at 60 min, and 0.91 % injected dose/g at 4 h.
Achieved mean liver radioactivity uptake of 8.32 % injected dose/g at 5 min, 3.66 % injected dose/g at 30 min, 1.92 % injected dose/g at 60 min, and 0.95 % injected dose/g at 4 h.
Reached mean kidney radioactivity uptake of 1.08 % injected dose/g at 5 min, 1.71 % injected dose/g at 30 min, 2.14 % injected dose/g at 60 min, and 1.49 % injected dose/g at 4 h.
Attained mean thyroid radioactivity uptake of 6.78 % injected dose/g at 5 min, 9.26 % injected dose/g at 30 min, 10.66 % injected dose/g at 60 min, and 9.69 % injected dose/g at 4 h.
Reached a maximum heart/blood ratio of 9:1 at 5 min, which decreased to 2.4:1 at 4 h.
Decreased heart uptake by 50% from peak (5 min) to 4 h.