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Art. -Nr.: HY-164977

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JCS-1

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JCS-1 is a potent DcpS PROTAC degrader. JCS-1 non-covalently binds DcpS with a RG3039-based warhead and recruits the E3 ligase VHL. JCS-1 promotes ubiquitination and degradation of DcpS at nanomolar concentrations (DC₅₀ in MOLM-14 cells: 87 nM). JCS-1 can be used for the research of AML and other DcpS-dependent genetic disorders.
(Pink: DcpS ligand (HY-102020); Blue: VHL ligand (HY-151227); Black: linker (HY-141230)).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.38%
CAS. Nr.: 3093519-24-2
Formel: C₆₂H₇₉N₉O₁₂S
Molecular Weight:1174.41

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

JCS-1 Chemical Structure

CAS. Nr.: 3093519-24-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

JCS-1 is a potent DcpS PROTAC degrader. JCS-1 non-covalently binds DcpS with a RG3039-based warhead and recruits the E3 ligase VHL. JCS-1 promotes ubiquitination and degradation of DcpS at nanomolar concentrations (DC₅₀ in MOLM-14 cells: 87 nM). JCS-1 can be used for the research of AML and other DcpS-dependent genetic disorders^[1]. (Pink: DcpS ligand (HY-102020); Blue: VHL ligand (HY-151227); Black: linker (HY-141230)).

IC₅₀ & Target^[1]

VHL

Alle PROTACs Isoform-spezifische Produkte anzeigen :

In Vitro

JCS-1 (0.1-10000 nM, 24 h) degrades DcpS in MOLM-14 cells in a dose-dependent manner with a DC₅₀ of 87 nM^[1].
JCS-1 (1 μM) degrades DcpS rapidly and continuously in MOLM-14 cells, with degradation occurring rapidly within 2 h of treatment and maximum degradation occurring between 12 and 24 h^[1].
JCS-1 (1 μM, every 3 days for 12 days) inhibits the proliferation and viability of MOLM-14 cells with an IC₅₀ value of 1.1 μM^[1].
JCS-1 (1 μM, 6 h) influences the mRNA pool of MOLM-14 cells with significant increase in SNORD99 and DDX24 expression^[1].
Degradation by JCS-1 is inhibited by the neddylation inhibitor MLN4924 (HY-70062) and proteasome inhibitor Epoxomicin (HY-13821) ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3093519-24-2
Appearance Solid
Molecular Weight 1174.41
Formel C₆₂H₇₉N₉O₁₂S
Color White to off-white
SMILES

O=C([C@H]1N(C([C@@H](N(CC2=C3C=CC=C2)C3=O)C(C)C)=O)C[C@H](O)C1)NCC4=CC=C(C5=C(C)N=CS5)C=C4OCCOCCOCCOCCOCCOCCOC6=CC=CC(CN7CCC(COC8=CC=CC9=NC(N)=NC(N)=C89)CC7)=C6
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 100 mg/mL (85.15 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.8515 mL

4.2575 mL

8.5149 mL

5 mM

0.1703 mL

0.8515 mL

1.7030 mL

10 mM

0.0851 mL

0.4257 mL

0.8515 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Swartzel, et al. Targeted Degradation of mRNA Decapping Enzyme DcpS by a VHL-Recruiting PROTAC. ACS chemical biology. 2022, 17(7), 1789–1798. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.8515 mL	4.2575 mL	8.5149 mL	21.2873 mL
	5 mM	0.1703 mL	0.8515 mL	1.7030 mL	4.2575 mL
	10 mM	0.0851 mL	0.4257 mL	0.8515 mL	2.1287 mL
	15 mM	0.0568 mL	0.2838 mL	0.5677 mL	1.4192 mL
	20 mM	0.0426 mL	0.2129 mL	0.4257 mL	1.0644 mL
	25 mM	0.0341 mL	0.1703 mL	0.3406 mL	0.8515 mL
	30 mM	0.0284 mL	0.1419 mL	0.2838 mL	0.7096 mL
	40 mM	0.0213 mL	0.1064 mL	0.2129 mL	0.5322 mL
	50 mM	0.0170 mL	0.0851 mL	0.1703 mL	0.4257 mL
	60 mM	0.0142 mL	0.0710 mL	0.1419 mL	0.3548 mL
	80 mM	0.0106 mL	0.0532 mL	0.1064 mL	0.2661 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
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JCS-1

PROTAC Library

Alle PROTACs Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

JCS-1 Related Classifications

HY-164977 Related Classifications