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Art. -Nr.: HY-149605

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KHK-IN-4

KHK-IN-4 (compound 14) is a potent ketohexokinase (KHK) inhibitor. KHK-IN-4 can be used for fructose metabolic disease research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3034829-40-5
Formel: C₁₈H₂₄F₂N₄O₂
Molecular Weight:366.41

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

KHK-IN-4 Chemical Structure

CAS. Nr.: 3034829-40-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

KHK-IN-4 (compound 14) is a potent ketohexokinase (KHK) inhibitor. KHK-IN-4 can be used for fructose metabolic disease research^[1].

Alle Ketohexokinase Isoform-spezifische Produkte anzeigen :

KHK-A
KHK-C

Cellular Effect

Cell Line	Type	Value	Description	References
Hepatocyte	IC₅₀	>150 μM Compound: ent-14	Toxicity in human Primary hepatocyte incubated for 48 hrs by Celltiter-Glo assay Toxicity in human Primary hepatocyte incubated for 48 hrs by Celltiter-Glo assay	[PMID: 37766386]
HepG2	IC₅₀	>150 μM Compound: ent-14	Cytotoxicity against human HepG2 cells measured after 48 hrs by microscopy based analysis Cytotoxicity against human HepG2 cells measured after 48 hrs by microscopy based analysis	[PMID: 37766386]
HepG2	IC₅₀	>150 μM Compound: ent-14	Mitotoxicity in human HepG2 cells incubated for 2 hrs by Celltiter-Glo assay Mitotoxicity in human HepG2 cells incubated for 2 hrs by Celltiter-Glo assay	[PMID: 37766386]
HepG2	IC₅₀	196 nM Compound: ent-14	Antiproliferative activity against human HepG2 cells incubated for 3 hrs by LC-MS analysis Antiproliferative activity against human HepG2 cells incubated for 3 hrs by LC-MS analysis	[PMID: 37766386]

Chemical Information

CAS. Nr. 3034829-40-5
Molecular Weight 366.41
Formel C₁₈H₂₄F₂N₄O₂
SMILES

C[C@H]1CCN1C2=NC(N3CC[C@@H](C3)CCC(O)=O)=C4C(C(F)(CC4)F)=N2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Guodong Zhu, et al. Discovery of a Novel Ketohexokinase Inhibitor with Improved Drug Distribution in Target Tissue for the Treatment of Fructose Metabolic Disease. J Med Chem. 2023 Oct 12;66(19):13501-13515. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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