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Art. -Nr.: HY-146682

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KS100

Kundenbewertung

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KS100 is a potent ALDH inhibitor with IC₅₀s of 230, 1542, 193 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS100 shows antiproliferative and anticancer effects with low low toxic. KS100 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS10600 induces apoptosis and cell cycle arrest at the G2/M phase.

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Reinheit: 99.61%
CAS. Nr.: 2408477-54-1
Formel: C₁₇H₁₄Br₃N₃O₂S
Molecular Weight:564.09

Speicherung:

4°C, sealed storage, away from moisture

* The compound is unstable in solutions, freshly prepared is recommended.

KS100 Chemical Structure

CAS. Nr.: 2408477-54-1

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Preis

Verfügbarkeit

Menge

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC₅₀: 230 nM (ALDH1A1); 1542 nM (ALDH2); 193 nM (ALDH3A1)^[1]

Alle Aldehyde Dehydrogenase (ALDH) Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	2.9 μM Compound: 3j; KS100	Antiproliferative activity against human HCT116 cells measured after 72 hrs by MTS assay Antiproliferative activity against human HCT116 cells measured after 72 hrs by MTS assay	[PMID: 31887569]
HT-29	IC₅₀	2.5 μM Compound: 3j; KS100	Antiproliferative activity against human HT-29 cells measured after 72 hrs by MTS assay Antiproliferative activity against human HT-29 cells measured after 72 hrs by MTS assay	[PMID: 31887569]
MM1.S	IC₅₀	2.1 μM Compound: 3j; KS100	Antiproliferative activity against human MM.1S cells measured after 72 hrs by MTS assay Antiproliferative activity against human MM.1S cells measured after 72 hrs by MTS assay	[PMID: 31887569]
NCI-H929	IC₅₀	0.3 μM Compound: 3j; KS100	Antiproliferative activity against human NCIH929 cells measured after 72 hrs by MTS assay Antiproliferative activity against human NCIH929 cells measured after 72 hrs by MTS assay	[PMID: 31887569]
RPMI-8226	IC₅₀	1.2 μM Compound: 3j; KS100	Antiproliferative activity against human RPMI8226 cells measured after 72 hrs by MTS assay Antiproliferative activity against human RPMI8226 cells measured after 72 hrs by MTS assay	[PMID: 31887569]
U-266	IC₅₀	1 μM Compound: 3j; KS100	Antiproliferative activity against human U266 cells measured after 72 hrs by MTS assay Antiproliferative activity against human U266 cells measured after 72 hrs by MTS assay	[PMID: 31887569]
UACC-903	IC₅₀	3.7 μM Compound: 3j; KS100	Antiproliferative activity against human UACC 903 cells measured after 72 hrs by MTS assay Antiproliferative activity against human UACC 903 cells measured after 72 hrs by MTS assay	[PMID: 31887569]

In Vitro

KS100 (compound 3j) (0-100 µM; 72 h) shows anti-proliferative activity with IC₅₀s of 3.7, 2.1, 2.9, 2.5, 0.3, 1.0, 1.2, 1.3, 2.1, 9.8 µM for UACC 903, 1205 Lu, HCT116, HT29, NCIH929, U266, RPMI8226, MM.1R, MM.1S, FF2441 cells, respectively^[1].
KS100 (5 µM, 24 h) induces apoptosis and cell cycle arrest at the G2/M phase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

HCT116, HT29 cells
Concentration:

5 µM
Incubation Time:

24 h
Result:

Induced cell apoptosis.

Apoptosis Analysis^[1]

Cell Line:

HCT116 cells
Concentration:

5 µM
Incubation Time:

24 h
Result:

Induced cell cycle arrest at G2/M phase.

Chemical Information

CAS. Nr. 2408477-54-1
Appearance Solid
Molecular Weight 564.09
Formel C₁₇H₁₄Br₃N₃O₂S
Color Yellow to orange
SMILES

N=C(SCC1=CC=C(C=C1)CN2C(C(C3=CC(Br)=CC(Br)=C32)=O)=O)N.Br
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* The compound is unstable in solutions, freshly prepared is recommended.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 125 mg/mL (221.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.7728 mL

8.8638 mL

17.7277 mL

5 mM

0.3546 mL

1.7728 mL

3.5455 mL

10 mM

0.1773 mL

0.8864 mL

1.7728 mL

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Dinavahi SS, et al. Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents. Eur J Med Chem. 2020 Feb 1;187:111962. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.7728 mL	8.8638 mL	17.7277 mL	44.3192 mL
	5 mM	0.3546 mL	1.7728 mL	3.5455 mL	8.8638 mL
	10 mM	0.1773 mL	0.8864 mL	1.7728 mL	4.4319 mL
	15 mM	0.1182 mL	0.5909 mL	1.1818 mL	2.9546 mL
	20 mM	0.0886 mL	0.4432 mL	0.8864 mL	2.2160 mL
	25 mM	0.0709 mL	0.3546 mL	0.7091 mL	1.7728 mL
	30 mM	0.0591 mL	0.2955 mL	0.5909 mL	1.4773 mL
	40 mM	0.0443 mL	0.2216 mL	0.4432 mL	1.1080 mL
	50 mM	0.0355 mL	0.1773 mL	0.3546 mL	0.8864 mL
	60 mM	0.0295 mL	0.1477 mL	0.2955 mL	0.7387 mL
	80 mM	0.0222 mL	0.1108 mL	0.2216 mL	0.5540 mL
	100 mM	0.0177 mL	0.0886 mL	0.1773 mL	0.4432 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

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CAS. Nr.:
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Menge:

KS100

MCE Bioactive Compound Library

Alle Aldehyde Dehydrogenase (ALDH) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

KS100 Related Classifications

HY-146682 Related Classifications