KY0418
KY0418 is a selective GPX4 inhibitor. KY0418 selectively and covalently modifies the selenocysteine residue of GPX4 and inhibits GPX4 activity. KY0418 induces ferroptosis and suppresses cell proliferation. KY0418 can be used for the study of ferroptosis and cancer.
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- CAS. Nr.: 3024369-07-8
- Formel: C28H35F3N8O3
- Molecular Weight:588.62
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
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GPX4 |
KY0418 (E46) potently inhibits proliferation of 786-O cells with an IC50 ≤ 100 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 3024369-07-8
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Molecular Weight 588.62
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Formel C28H35F3N8O3
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SMILES
O=C(N1C2=CC=C(N3C[C@H](C)O[C@H](C)C3)N=C2)C4(CCCC4)C5=C1N=C(COC(N6[C@@H](C(F)(F)F)CCC6)=N)N=C5N
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
KY0418 Related Classifications
HY-186143 Related Classifications
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