Lecimibide
Based on 1 Customer Validation
Lecimibide (DuP 128) is a potent and specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor for antihyperlipidemia research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.54%
- CAS. Nr.: 130804-35-2
- Formel: C34H40F2N4OS
- Molecular Weight:590.77
-
Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
-
HY-119738
OSMI-1O-GlcNAc Transferase Inhibitor -
HY-N6719
Fumonisin B1Sphingosine N-acyltransferase Inhibitor -
HY-135425
10,12-Tricosadiynoic acidACOX1 Inhibitor -
HY-114361
OSMI-4OGT Inhibitor -
HY-N6739
BeauvericinAnticancer Fungal Mycotoxin -
HY-100400A
K-604 dihydrochlorideACAT1 Inhibitor -
HY-117832
Pyripyropene ASOAT2/ACAT2 Inhibitor -
HY-100401
PactimibeACAT1/2 Inhibitor -
HY-136282
ST045849OGT Inhibitor -
HY-N6723
Fumonisin B2Ceramide Synthase Inhibitor -
HY-100401A
Pactimibe sulfateACAT1/2 Inhibitor -
HY-N4193
GlabrolAcyltransferase Inhibitor
Biologische Aktivität
Beschreibung
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| J774 | IC50 |
1000 nM
Compound: 1
|
Concentration required to inhibit 50% activity of J774 macrophage cholesterol esterification
Concentration required to inhibit 50% activity of J774 macrophage cholesterol esterification
|
[PMID: 7707310] |
| Macrophage | IC50 |
1 μM
Compound: table I
|
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) in J774 Macrophage cell culture by using J774 assay.
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) in J774 Macrophage cell culture by using J774 assay.
|
10.1016/0960-894X(95)00001-A |
| Macrophage | IC50 |
1 μM
Compound: DuP-128
|
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture
Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture
|
10.1016/0960-894X(95)00003-C |
In Vitro
Lecimibide (DuP 128)(10 μM, 24 h) can inhibit 85% of the cellular esterification reaction in HepG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 130804-35-2
-
Appearance Solid
-
Molecular Weight 590.77
-
Formel C34H40F2N4OS
-
Color Colorless to off-white
-
SMILES
O=C(NC1=CC=C(F)C=C1F)N(CCCCCSC2=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N2)CCCCCCC
-
Synonyms
DuP 128
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
-
Data Sheet (269 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
Verweise
[1]. L J Wilcox, et al. Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP. J Lipid Res. 2001 May;42(5):725-34. [Content Brief]
[2]. J R Burnett, et al. Inhibition of cholesterol esterification by DuP 128 decreases hepatic apolipoprotein B secretion in vivo: effect of dietary fat and cholesterol. Biochim Biophys Acta. 1998 Jul 31;1393(1):63-79. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Lecimibide Related Classifications
HY-16281 Related Classifications
Powered by Bioz