LFS-1107
LFS-1107 is a reversible CRM1 inhibitor (Kd: 12.5 pM). LFS-1107 can selectively eliminate extranodal natural killer/T cell lymphoma (ENKTL) cells and can be used for cancer research.
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- CAS. Nr.: 1799330-91-8
- Formel: C12H11N5OS2
- Molecular Weight:305.38
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Biologische Aktivität
Beschreibung
IC50 & Target
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COX-2 |
In Vitro
LFS-1107 (4-9 μM, 72 h) can selectively eliminate ENKTL cells while sparing normal human PBMC with good safety profile in PBMC cell lines[1].
LFS-1107 (0.15-500 μM, 24 h) barely exhibits any effects in human platelets[1].
LFS-1107 (50-200 nM, 3 h) can lead to nuclear accumulation IκBα in 293T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SNK6, HANK-1
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Concentration:0-800 nM
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Incubation Time:72 h
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Result:Achieved IC50 value of 26 nM in SNK6 cell line and 36 nM in HANK-1 cell line.
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Cell Line:SNK6
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Concentration:62.5 nM, 125 nM, 250 nM, 500 nM, 1000 nM
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Incubation Time:3 h
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Result:Suppressed the expression of CRM1 in a dose-dependent manner. Downregulated the expression of proinflammatory and proliferative proteins p65, COX-2, c-Myc, and Survivin in a dose dependent manner.
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Cell Line:293T cells
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Concentration:50 nM, 100 nM, 200 nM
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Incubation Time:3 h
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Result:Could lead to nuclear accumulation of IκBα in a dose dependent manner.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SNK6 cell xenograft mouse model[1]
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Dosage:10 mg/kg
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Administration:Intraperitoneal injection (i.p.), once a week
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Result:Extended mouse survival and Eliminated tumor cells.
Chemical Information
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CAS. Nr. 1799330-91-8
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Molecular Weight 305.38
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Formel C12H11N5OS2
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SMILES
O=S(C1=NN=NN1C2=CC=CC=C2)/C=C/CCN=C=S
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
LFS-1107 Related Classifications
HY-157136 Related Classifications
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