LG190178
LG190178 is a non-steroidal vitamin D receptor (VDR) ligand that can induce the formation of heterodimer complexes between VDR and retinoid X receptor (RXR), stabilizing the agonistic conformation of the VDR ligand-binding domain and promoting its interaction with co-activators. LG190178 has functions in regulating calcium homeostasis, bone mineralization, as well as cell proliferation, differentiation, and apoptosis, making it useful for research in psoriasis, osteoporosis, and cancer.
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- CAS. Nr.: 233268-81-0
- Formel: C28H42O5
- Molecular Weight:458.63
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
>10 μM
Compound: 3a, LG190178, Diastereomeric mixture
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Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of transcriptional activity by luciferase and beta-galactosidase reporter gene assay
Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of transcriptional activity by luciferase and beta-galactosidase reporter gene assay
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[PMID: 23462715] |
| HL-60 | EC50 |
30 nM
Compound: 3a, LG190178, Diastereomeric mixture
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Induction of monocytic cell differentiation in human HL60 cells
Induction of monocytic cell differentiation in human HL60 cells
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[PMID: 23462715] |
| HL-60 | ED50 |
44 nM
Compound: 7
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Vitamin D3 agonistic activity as effective dose for HL-60 monocytic cell differentiation
Vitamin D3 agonistic activity as effective dose for HL-60 monocytic cell differentiation
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[PMID: 16019211] |
| LNCaP | EC50 |
20 nM
Compound: 3a, LG190178, Diastereomeric mixture
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Growth inhibition of human LNCAP cells
Growth inhibition of human LNCAP cells
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[PMID: 23462715] |
| SC-3 | IC50 |
19 nM
Compound: 7
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Androgen antagonistic activity as inhibitory concentration against testosterone-induced SC-3 cell proliferation
Androgen antagonistic activity as inhibitory concentration against testosterone-induced SC-3 cell proliferation
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[PMID: 16019211] |
Chemical Information
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CAS. Nr. 233268-81-0
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Molecular Weight 458.63
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Formel C28H42O5
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SMILES
OCC(O)COC1=CC=C(C(C2=CC=C(OCC(O)C(C)(C)C)C(C)=C2)(CC)CC)C=C1C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
LG190178 Related Classifications
HY-117182 Related Classifications
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