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Art. -Nr.: HY-132989

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Mal-Deferoxamine

Name: Mal-Deferoxamine
Brand: MedChemExpress
SKU: HY-132989
Price: 340.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Mal-Deferoxamine is a maleimide-functionalized trihydroxamate siderophore derivative that can be isolated from Streptomyces pilosus. Mal-Deferoxamine possesses highly specific Fe (III) chelating ability, and the stability of complexes formed between it and non-Fe (III) metal ions is significantly lower. Mal-Deferoxamine exhibits growth inhibitory effects against Gram-positive bacteria, but shows no obvious inhibitory activity against Gram-negative bacteria (MIC>50 μM). Mal-Deferoxamine is mainly suitable for scientific research in hematology and related fields.

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Reinheit: 95.0%
CAS. Nr.: 1638156-31-6
Formel: C₃₂H₅₃N₇O₁₁
Molecular Weight:711.80

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Mal-Deferoxamine Chemical Structure

CAS. Nr.: 1638156-31-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

RDC Bifunctional Chelator

In Vitro

Mal-Deferoxamine (0.1-20 mM Fe(III); 0.25-24 h) is highly selective for Fe(III) over Al(III) and Cr(III), adsorbs Fe(III) via a monolayer, endothermic, spontaneous process following pseudo-second-order kinetics, with a maximal adsorption capacity of 137.93 mg g^-1^[1].
Mal-Deferoxamine (up to 50 μM) and its Ga³⁺-complex do not exhibit in vitro antibacterial activity against Bacillus subtilis ATCC 6633, Staphylococcus aureus SG511, Micrococcus luteus ATCC 10240, Mycobacterium vaccae IMET 10670, or Pseudomonas aeruginosa K799/wt at concentrations up to 50 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1638156-31-6
Appearance Solid
Molecular Weight 711.80
Formel C₃₂H₅₃N₇O₁₁
Color White to off-white
SMILES

O=C1C=CC(N1CCC(NCCCCCN(C(CCC(NCCCCCN(C(CCC(NCCCCCN(C(C)=O)O)=O)=O)O)=O)=O)O)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 83.33 mg/mL (117.07 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.4049 mL

7.0244 mL

14.0489 mL

5 mM

0.2810 mL

1.4049 mL

2.8098 mL

10 mM

0.1405 mL

0.7024 mL

1.4049 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Pawlaczyk M, Schroeder G. Deferoxamine-modified hybrid materials for direct chelation of Fe (III) ions from aqueous solutions and indication of the competitiveness of in vitro complexing toward a biological system[J]. ACS omega, 2021, 6(23): 15168-15181.

[2]. Juárez-Hernández RE, et al. Syntheses of Siderophore-Drug Conjugates Using a Convergent Thiol-Maleimide System. ACS Med Chem Lett. 2012;3(10):799-803. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.4049 mL	7.0244 mL	14.0489 mL	35.1222 mL
	5 mM	0.2810 mL	1.4049 mL	2.8098 mL	7.0244 mL
	10 mM	0.1405 mL	0.7024 mL	1.4049 mL	3.5122 mL
	15 mM	0.0937 mL	0.4683 mL	0.9366 mL	2.3415 mL
	20 mM	0.0702 mL	0.3512 mL	0.7024 mL	1.7561 mL
	25 mM	0.0562 mL	0.2810 mL	0.5620 mL	1.4049 mL
	30 mM	0.0468 mL	0.2341 mL	0.4683 mL	1.1707 mL
	40 mM	0.0351 mL	0.1756 mL	0.3512 mL	0.8781 mL
	50 mM	0.0281 mL	0.1405 mL	0.2810 mL	0.7024 mL
	60 mM	0.0234 mL	0.1171 mL	0.2341 mL	0.5854 mL
	80 mM	0.0176 mL	0.0878 mL	0.1756 mL	0.4390 mL
	100 mM	0.0140 mL	0.0702 mL	0.1405 mL	0.3512 mL

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Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
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CAS. Nr.:
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Mal-Deferoxamine

p-SCN-Bn-deferoxamine

Maleimide-DOTA

Maleimide-NOTA

2-Aminoethyl-mono-amide-DOTA-tris(tBu ester)

p-NH2-Bn-DOTA

Butyne-DOTA

Bz-DTPA

DOTA-Thiol

DOTA-GA(tBu)4

Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester)

Butyne-DOTA-tris(t-butyl ester)

NO2A-Butyne

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Bioz

Mal-Deferoxamine

p-SCN-Bn-deferoxamine

Maleimide-DOTA

Maleimide-NOTA

2-Aminoethyl-mono-amide-DOTA-tris(tBu ester)

p-NH2-Bn-DOTA

Butyne-DOTA

Bz-DTPA

DOTA-Thiol

DOTA-GA(tBu)4

Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester)

Butyne-DOTA-tris(t-butyl ester)

NO2A-Butyne

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Mal-Deferoxamine Related Classifications

HY-132989 Related Classifications

Bioz