MODAG-005
MODAG-005 is a blood-brain barrier-permeable PET probe precursor for α-synuclein (α‑Syn) aggregates, with a Ki value of 0.4 nM and a Kd value of 0.2 nM. MODAG-005 specifically binds to high-affinity sites within the tubular cavity of α-synuclein fibrils, and exhibits selectivity over tau protein fibrils and β-amyloid (A1-42) fibrils. MODAG-005 is applicable to the research of multiple system atrophy and Parkinson's disease.
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- CAS. Nr.: 2648041-73-8
- Formel: C15H13BrN4
- Molecular Weight:329.19
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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α-synuclein Aggregation 0.2 nM (Kd) |
MAO-B 0.8 μM (IC50) |
[3H]MODAG-005 exhibits subnanomolar binding affinity for recombinant human α-synuclein fibrils, shows 36-fold lower affinity for tau fibrils and over 100-fold lower affinity for Aβ1-42 fibrils, with an MAO-B IC50 of 0.8 μM and no other relevant off-target binding[1].
[3H]MODAG-005 binds specifically to α-synuclein pathology in post-mortem human multiple system atrophy (MSA) brain tissues, with a high-affinity binding site (Kd = 0.19 nM); it shows no specific binding in control brain tissues and does not bind to monoamine oxidase B (MAO-B) in MSA tissues[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
[11C]MODAG-005 (intravenous administration; single bolus injection) binds specifically to α-synuclein fibrils in rats with striatal injections[1].
[11C]MODAG-005 (intravenous administration; single bolus injection) exhibits specific, pathology-associated binding to intracellular α-synuclein aggregates in α-SynA30P transgenic mice[1].
[11C]MODAG-005 (intravenous administration; single bolus injection) exhibits favorable pharmacokinetic properties in healthy cynomolgus monkeys, including rapid brain uptake, rapid clearance, and detectable plasma metabolism[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2648041-73-8
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Molecular Weight 329.19
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Formel C15H13BrN4
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SMILES
CNC1=CC=C(C=C1)C2=NNC(C3=CC=NC(Br)=C3)=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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