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Art. -Nr.: HY-145654

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MRS-4203

MRS-4203 is an adenosine kinase (ADK) inhibitor (IC₅₀ = 88 nM). MRS-4203 prevents adenosine phosphorylation, thereby reducing global DNA methylation in a concentration-dependent manner. MRS-4203 can be used for the research of cervical adenocarcinoma.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1962174-21-5
Formel: C₂₅H₂₄N₄O₂
Molecular Weight:412.48

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

MRS-4203 Chemical Structure

CAS. Nr.: 1962174-21-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Anti-cancerOthers

Anti-cancer

MRS-4203 (0.1-1 μM; 24 h) reduces global DNA methylation in HeLa cells in a concentration-dependent manner, with a 52% reduction at 1 μM after 24 h^[1].

Others

MRS-4203 is a potent ADK inhibitor with an IC₅₀ of 88 nM in a cell-free ADK phosphorylation assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS. Nr. 1962174-21-5
Molecular Weight 412.48
Formel C₂₅H₂₄N₄O₂
SMILES

O[C@H]1[C@]2(N3C4=NC=NC(NC5=CC=CC=C5)=C4C(C6=CC=CC=C6)=C3)[C@@]([C@@H]([C@H]1O)C)([H])C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wahba AE, et al. Adenosine Kinase Expression Determines DNA Methylation in Cancer Cell Lines. ACS pharmacology & translational science. 2021 Apr 09;4(2):680-686. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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