Art. -Nr.: HY-141514

MSA-2 dimer

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (K_d=145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer is bound to STING as a non-covalent dimer exhibiting higher permeability than cyclic dinucleotide.

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Reinheit: 99.88%
CAS. Nr.: 2377881-92-8
Formel: C₂₉H₂₈O₈S₂
Molecular Weight:568.66

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

MSA-2 dimer Chemical Structure

CAS. Nr.: 2377881-92-8

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Kd: 145 μM (STING)^[1]

In Vivo

MSA-2 dimer (60 mg/kg; p.o.; 50 days) inhibits tumor growth and prolongs overall survival^[1].
? MSA-2 dimer (40 mg/kg; s.c.; 25 days) induces complete tumor regression^[1].
? MSA-2 dimer (60 mg/kg; p.o.; 4 hours) increases proinflammatory cytokine (IFN-β) level in tumors^[1].
? MSA-2 dimer (60 mg/kg; s.c.; 4 hours) concentrations is observed in tumors than in plasma or other nontumor tissues ^[1].
? MSA-2 dimer (THP-1 cells) induces phosphorylation of both TBK1 and IR. MSA-2 dimer (10 μM and 33 μM; macrophages) induces IFN-β^[1].
? MSA-2 dimer also exhibits dose-dependent antitumor activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

B16F10 tumor-bearing mice
Dosage:

60 mg/kg
Administration:

P.o.; 50 days
Result:

Inhibited tumor growth and prolonged overall survival.

Animal Model:

C57BL6 mice
Dosage:

40 mg/kg
Administration:

S.c.; 25 days
Result:

Induced complete tumor regression.

Animal Model:

C57BL6 mice
Dosage:

60 mg/kg
Administration:

P.o.; 4 hours
Result:

Increased proinflammatory cytokine (IFN-β) level in tumors.

Animal Model:

C57BL6 mice
Dosage:

50 mg/kg
Administration:

S.c.; 4 hours
Result:

MSA-2 concentrations were observed in tumors than in plasma or other nontumor tissues.

Chemical Information

CAS. Nr. 2377881-92-8
Appearance Solid
Molecular Weight 568.66
Formel C₂₉H₂₈O₈S₂
Color White to yellow
SMILES

O=C(CCC(C1=CC2=C(C=C(C(CCCC3=CC4=C(C=C3OC)SC(C(CCC(O)=O)=O)=C4)=C2)OC)S1)=O)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Journal Impact Factor

Viruses

A Non-Nucleotide STING Agonist MSA-2 Synergized with Manganese in Enhancing STING Activation to Elicit Potent Anti-RNA Virus Activity in the Cells. [Abstract]

2023 Oct 24;15(11):2138. PMID: 38005816

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 70 mg/mL (123.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.7585 mL

8.7926 mL

17.5852 mL

5 mM

0.3517 mL

1.7585 mL

3.5170 mL

10 mM

0.1759 mL

0.8793 mL

1.7585 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 1.75 mg/mL (3.08 mM); Clear solution

This protocol yields a clear solution of ≥ 1.75 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (17.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 1.75 mg/mL (3.08 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 1.75 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (17.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 1.75 mg/mL (3.08 mM); Clear solution

This protocol yields a clear solution of ≥ 1.75 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (17.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Pan BS, et al. An orally available non-nucleotide STING agonist with antitumor activity. Science. 2020;369(6506):eaba6098. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.7585 mL	8.7926 mL	17.5852 mL	43.9630 mL
	5 mM	0.3517 mL	1.7585 mL	3.5170 mL	8.7926 mL
	10 mM	0.1759 mL	0.8793 mL	1.7585 mL	4.3963 mL
	15 mM	0.1172 mL	0.5862 mL	1.1723 mL	2.9309 mL
	20 mM	0.0879 mL	0.4396 mL	0.8793 mL	2.1982 mL
	25 mM	0.0703 mL	0.3517 mL	0.7034 mL	1.7585 mL
	30 mM	0.0586 mL	0.2931 mL	0.5862 mL	1.4654 mL
	40 mM	0.0440 mL	0.2198 mL	0.4396 mL	1.0991 mL
	50 mM	0.0352 mL	0.1759 mL	0.3517 mL	0.8793 mL
	60 mM	0.0293 mL	0.1465 mL	0.2931 mL	0.7327 mL
	80 mM	0.0220 mL	0.1099 mL	0.2198 mL	0.5495 mL
	100 mM	0.0176 mL	0.0879 mL	0.1759 mL	0.4396 mL

Keywords

MSA-2 dimer

1 Cited Publications

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MSA-2 dimer

MCE Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) MSA-2 dimer

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

MSA-2 dimer

MCE Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) MSA-2 dimer

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

MSA-2 dimer Related Classifications

HY-141514 Related Classifications