Norbaeocystin
Norbaeocystin is an intermediate/minor metabolite naturally present in the psilocybin biosynthetic pathway of hallucinogenic mushrooms (Psilocybe spp.). Norbaeocystin has weak or no affinity for the serotonin 2A (5-HT2A) receptor and does not induce receptor activation. Norbaeocystin is rapidly metabolized by monoamine oxidase, and thus does not participate in centrally mediated psychedelic effects. Norbaeocystin can be used for studies on biological pathways associated with hallucinogenic effects.
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- CAS. Nr.: 21420-59-7
- Formel: C10H13N2O4P
- Molecular Weight:256.19
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Long-Evans (male, adult, PND 90-120)[1]
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Dosage:0.13 mg/kg; 0.25 mg/kg; 1.26 mg/kg; 2.52 mg/kg (broth vehicle); 0.1 mg/kg; 0.2 mg/kg; 1.0 mg/kg; 2.0 mg/kg (distilled water vehicle)
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Administration:p.o.; single dose
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Result:Failed to increase the rate of head twitch responses at any dose tested in either vehicle.
Showed no significant effect across doses in broth vehicle.
Showed no significant effect across doses in water vehicle.
Had no significant effect on locomotor behavior (total distance travelled or rearing events).
Chemical Information
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CAS. Nr. 21420-59-7
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Molecular Weight 256.19
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Formel C10H13N2O4P
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SMILES
O=P(O)(OC1=CC=CC2=C1C(CCN)=CN2)O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Adams AM, et al. Development of an -based norbaeocystin production platform and evaluation of behavioral effects in rats. Metabolic engineering communications. 2022 Jun;14:e00196. [Content Brief]
[2].
Sherwood AM, et al. Synthesis and Biological Evaluation of Tryptamines Found in Hallucinogenic Mushrooms: Norbaeocystin, Baeocystin, Norpsilocin, and Aeruginascin. J Nat Prod. 2020 Feb 28;83(2):461-467.
[Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Norbaeocystin Related Classifications
HY-168809 Related Classifications
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- Norbaeocystin
- 21420-59-7
- Drug Intermediate
- 5-HT Receptor
- monoamine oxidase
- tryptamine biosynthetic substrate
- male Long-Evans rats
- 4-hydroxyindole
- hallucinogenic effect-related biological pathways
- serotonin 2A (5-HT2A) receptor
- rats
- recombinant E. coli BL21 Star? (DE3) strain Nor1
- blood-brain barrier
- Inhibitor
- inhibitor
- inhibit