Nrf2 activator-2
Based on 2 publication(s) in Google Scholar
Nrf2 activator-2 is an Nrf2 activator with binding affinity for Keap1, with an EC50 of 2.9 μM. Nrf2 activator-2 binds to Keap1, stabilizes the protein, inhibits the Keap1-Nrf2 interaction, and reduces the ubiquitination level of Nrf2. Nrf2 activator-2 can be used in cancer-related research.
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- Reinheit: 99.20%
- CAS. Nr.: 2770448-53-6
- Formel: C20H17BrO3
- Molecular Weight:385.25
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Publications Citing Use of MedChemExpress (MCE) Nrf2 activator-2
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Biologische Aktivität
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Nrf2 2.9 μM (EC50) |
Nrf2 activator-2 (O15) (2.9-20 μM) potently activates Nrf2 in 293T cells with an EC50 of 2.9 μM and an activation fold of 2.57 at 20 μM[1].
Nrf2 activator-2 (O15) binds stably to purified Keap1 protein (PDB ID: 3VNG) via multiple interactions, inhibiting the Keap1-Nrf2 protein-protein interaction to activate Nrf2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2770448-53-6
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Appearance Solid
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Molecular Weight 385.25
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Formel C20H17BrO3
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Color Off-white to light yellow
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SMILES
CC1(CCC2=C3OC(C(C4=CC=CC=C4)=CC3=CC(Br)=C2O1)=O)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
Lösungsmittel & Löslichkeit
DMSO : 25 mg/mL (64.89 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (278 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
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Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5957 mL | 12.9786 mL | 25.9572 mL | 64.8929 mL |
| 5 mM | 0.5191 mL | 2.5957 mL | 5.1914 mL | 12.9786 mL | |
| 10 mM | 0.2596 mL | 1.2979 mL | 2.5957 mL | 6.4893 mL | |
| 15 mM | 0.1730 mL | 0.8652 mL | 1.7305 mL | 4.3262 mL | |
| 20 mM | 0.1298 mL | 0.6489 mL | 1.2979 mL | 3.2446 mL | |
| 25 mM | 0.1038 mL | 0.5191 mL | 1.0383 mL | 2.5957 mL | |
| 30 mM | 0.0865 mL | 0.4326 mL | 0.8652 mL | 2.1631 mL | |
| 40 mM | 0.0649 mL | 0.3245 mL | 0.6489 mL | 1.6223 mL | |
| 50 mM | 0.0519 mL | 0.2596 mL | 0.5191 mL | 1.2979 mL | |
| 60 mM | 0.0433 mL | 0.2163 mL | 0.4326 mL | 1.0815 mL |
Nrf2 activator-2 Related Classifications
HY-145879 Related Classifications
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