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Art. -Nr.: HY-112889

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Oxythiamine diphosphate

1 Cited Publications

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Oxythiamin diphosphate is a potent transketolase (TK) inhibitor.

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CAS. Nr.: 10497-04-8
Formel: C₁₂H₁₇N₃O₈P₂S
Molecular Weight:425.29

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Oxythiamine diphosphate Chemical Structure

CAS. Nr.: 10497-04-8

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Biologische Aktivität

Beschreibung

Oxythiamin diphosphate is a potent transketolase (TK) inhibitor^[1].

IC₅₀ & Target

Ki: 30 nM (thiamine pyrophosphate)^[1].

In Vitro

Rat liver TK is inhibited at 50% by oxythiamine diphosphate in concentrations of 0.02–0.2 μM. I₅₀ value of Oxythiamine diphosphate for yeast transketolase is approximately 0.03 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 10497-04-8
Molecular Weight 425.29
Formel C₁₂H₁₇N₃O₈P₂S
SMILES

CC1=C(CCOP(OP(O)(O)=O)([O-])=O)SC=[N+]1CC2=CN=C(C)NC2=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Cell Chem Biol

Pharmacological perturbation of thiamine metabolism sensitizes Pseudomonas aeruginosa to multiple antibacterial agents. [Abstract]

2022 Aug 18;29(8):1317-1324.e5. PMID: 35901793

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Tylicki A, et al. Thiamine and selected thiamine antivitamins - biological activity and methods of synthesis. Biosci Rep. 2018;38(1):BSR20171148. Published 2018 Jan 10. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Oxythiamine diphosphate

1 Cited Publications

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Oxythiamine diphosphate

Publications Citing Use of MedChemExpress (MCE) Oxythiamine diphosphate

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Publications (1)

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Oxythiamine diphosphate Related Classifications

Art. -Nr.: HY-112889