PDE10A-IN-4
PDE10A-IN-4 (compound 38) is a compound used to inhibit schizophrenia. As a PDE10A inhibitor, it is less effective than placebo in inhibiting acute schizophrenia and does not show antipsychotic effect.
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- CAS. Nr.: 898563-49-0
- Formel: C25H20N4O
- Molecular Weight:392.45
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf21 | IC50 |
1.34 nM
Compound: 3, MP-10
|
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillation counting
Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillation counting
|
[PMID: 20450197] |
| Sf9 | IC50 |
0.37 nM
Compound: 9
|
Inhibition of rat recombinant PDE10A transfected in Sf9 cells
Inhibition of rat recombinant PDE10A transfected in Sf9 cells
|
[PMID: 19630403] |
Chemical Information
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CAS. Nr. 898563-49-0
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Molecular Weight 392.45
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Formel C25H20N4O
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SMILES
CN(N=C1C2=CC=C(OCC3=NC4=C(C=C3)C=CC=C4)C=C2)C=C1C5=CC=NC=C5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)