pDI
pDI is a peptide. pDI inhibits MDM2-p53 and MDMX-p53 interactions with IC50s of 10 and 100 nM respectively. pDI can be used in the research of colorectal cancer.
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- CAS. Nr.: 1443628-44-1
- Formel: C71H99N17O19
- Molecular Weight:1494.65
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
IC50: 10 nM (MDM2-p53); 100 nM (MDMX-p53)[2]
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 1443628-44-1
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Molecular Weight 1494.65
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Formel C71H99N17O19
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Sequence
Leu-Thr-Phe-Glu-His-Tyr-Trp-Ala-Gln-Leu-Thr-Ser-NH2
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Sequence Shortening
LTFEHYWAQLTS-NH2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Xu L, et al. Design, Synthesis, and Biological Evaluation of Lysine-Stapled Peptide Inhibitors of p53-MDM2/MDMX Interactions with Potent Antitumor Activity In Vivo. J Med Chem. 2024 Oct 10;67(19):17893-17904. [Content Brief]
[2]. Hu B, et al. Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX. Cancer Res. 2007 Sep 15;67(18):8810-7. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
pDI Related Classifications
HY-P11256 Related Classifications
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