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Art. -Nr.: HY-W291147

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Pifexole

Pifexole is a biologically active 3,5-disubstituted-1,2,4-oxadiazole compound. Pifexole exhibits antispasmodic and muscle relaxant activities, with no effect on monosynaptic knee-jerk reflex. Pifexole can be used in studies related to muscle relaxation and spasm.

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CAS. Nr.: 27199-40-2
Formel: C₁₃H₈ClN₃O
Molecular Weight:257.68

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pifexole Chemical Structure

CAS. Nr.: 27199-40-2

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Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vivo

Pifexole (5-20 mg/kg; i.v.; single administration; monitored for approximately 20-25 min) inhibits the polysynaptic crossed extensor reflex in cats anesthetized with chloralose and urethane, with inhibition rates of 81.6% and 93.1% at 5 mg/kg and 10 mg/kg, respectively, but does not affect the monosynaptic patellar tendon reflex at 10-20 mg/kg^[2].
Pifexole (15.4-200 mg/kg; p.o.) inhibits electroshock-induced convulsions in rats and mice with ED₅₀ values of 17.5 mg/kg and 15.4 mg/kg, respectively, and inhibits strychnine-induced convulsions in both species with an ED₅₀ of 96 mg/kg, while antagonizing nicotine toxicity in mice with an ED₅₀ of 30 mg/kg. Pifexole also reduces muscle strength in mice by 25% and 35% at 100 mg/kg and 200 mg/kg, respectively, inhibits spontaneous activity in mice at 100 mg/kg, and reduces morphine-induced excitation and hyperactivity at 200 mg/kg^[2]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Polysynaptic crossed extensor and monosynaptic patellar reflex assays in chloralose-urethane-anesthetized cats^[2]
Dosage:

5, 10, 20 mg/kg
Administration:

i.v.; single administration; monitored for approximately 20-25 min
Result:

Reduced the polysynaptic crossed extensor reflex by 81.6% and 93.1% at 5 and 10 mg/kg, respectively.
Did not affect the monosynaptic patellar reflex at 10-20 mg/kg.

Animal Model:

Nicotine toxicity^[2]
Dosage:

30, 100, 200 mg/kg
Administration:

p.o. for the nicotine toxicity assay
Result:

Antagonized nicotine toxicity with an ED50 of 30 mg/kg.
Reduced muscle strength by 25% and 35% at 100 and 200 mg/kg, respectively.
Suppressed spontaneous locomotor activity at 100 mg/kg and reduced morphine-induced excitation and hypermotility at 200 mg/kg.

Chemical Information

CAS. Nr. 27199-40-2
Molecular Weight 257.68
Formel C₁₃H₈ClN₃O
SMILES

ClC=1C=CC=CC1C2=NC(=NO2)C=3C=CN=CC3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Tolmachev A, et al. Expanding Synthesizable Space of Disubstituted 1,2,4-Oxadiazoles. ACS combinatorial science. 2016 Oct 10;18(10):616-624. [Content Brief]

[2]. Harsányi K, et al. Neue 1,2,4-Oxadiazol-Derivate und Verfahren zur Herstellung derselben. DE1920037A1. 1970.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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