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Art. -Nr.: HY-177437A

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(+)-PM 92131

(+)-PM 92131 is the active enantiomer of (±)-PM 92131 (HY-177437). (+)-PM 92131 is a non-nucleoside HIV-1 inhibitor. (+)-PM 92131 has an anti-HIV-1 activity with EC₅₀s of 0.8 and 0.6 μM for HIV-1 RF strain in XTT cytoprotection and syncytium-forming assay, respectively. (+)-PM 92131 can be used for HIV infections research.

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CAS. Nr.: 167937-11-3
Formel: C₁₆H₂₀O₃
Molecular Weight:260.33

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

(+)-PM 92131 Chemical Structure

CAS. Nr.: 167937-11-3

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Biologische Aktivität
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Biologische Aktivität

Beschreibung

Alle HIV Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
CEM-SS	EC₅₀	0.6 μM Compound: PM-92131(+)	Effective concentration required for 50% inhibition of viral replication by syncytium-forming assay carried out in CEM-SS cells Effective concentration required for 50% inhibition of viral replication by syncytium-forming assay carried out in CEM-SS cells	10.1016/0960-894X(95)00260-Z
CEM-SS	EC₅₀	0.8 μM Compound: PM-92131(+)	Effective concentration required for 50% inhibition of viral replication by XTT cytoprotection assay carried out in CEM-SS cells Effective concentration required for 50% inhibition of viral replication by XTT cytoprotection assay carried out in CEM-SS cells	10.1016/0960-894X(95)00260-Z
CEM-SS	EC₅₀	1.3 μM Compound: PM-92131(+/-)	Effective concentration required for 50% inhibition of viral replication by XTT cytoprotection assay carried out in CEM-SS cells Effective concentration required for 50% inhibition of viral replication by XTT cytoprotection assay carried out in CEM-SS cells	10.1016/0960-894X(95)00260-Z
CEM-SS	EC₅₀	1.7 μM Compound: PM-92131(+/-)	Effective concentration required for 50% inhibition of viral replication by syncytium-forming assay carried out in CEM-SS cells Effective concentration required for 50% inhibition of viral replication by syncytium-forming assay carried out in CEM-SS cells	10.1016/0960-894X(95)00260-Z
CEM-SS	IC₅₀	134.6 μM Compound: PM-92131(+)	Compound was evaluated for inhibitory activity against cell growth Compound was evaluated for inhibitory activity against cell growth	10.1016/0960-894X(95)00260-Z
CEM-SS	IC₅₀	42.1 μM Compound: PM-92131(+)	Compound was evaluated for inhibitory activity against cell growth Compound was evaluated for inhibitory activity against cell growth	10.1016/0960-894X(95)00260-Z
CEM-SS	IC₅₀	45.7 μM Compound: PM-92131(+/-)	Compound was evaluated for inhibitory activity against cell growth Compound was evaluated for inhibitory activity against cell growth	10.1016/0960-894X(95)00260-Z
CEM-SS	IC₅₀	53.8 μM Compound: PM-92131(+/-)	Compound was evaluated for inhibitory activity against cell growth Compound was evaluated for inhibitory activity against cell growth	10.1016/0960-894X(95)00260-Z

Chemical Information

CAS. Nr. 167937-11-3
Molecular Weight 260.33
Formel C₁₆H₂₀O₃
SMILES

C[C@@]12[C@@]3(C(C)(CCC2)C)[C@](C([C@H]1C4=COC=C4)=O)([H])O3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Jesús A, et al. A novel non nucleoside compound with high in vitro anti-HIV-1 activity. Absolute stereochemistry determination[J]. Bioorganic & Medicinal Chemistry Letters, 1995, 5(14): 1471-1474.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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(+)-PM 92131

Alle HIV Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

(+)-PM 92131 Related Classifications

HY-177437A Related Classifications