pNPPT cyclohexanamine
pNPPT cyclohexanamine (p-Nitrophenyl phosphorothioate cyclohexanamine) is a dianionic aryl thiophosphate monoester substrate of PP1γ (protein phosphatase 1γ). PP1γ catalyzes the hydrolysis of pNPPT cyclohexanamine.
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- CAS. Nr.: 167698-72-8
- Formel: C18H32N3O5PS
- Molecular Weight:433.50
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Beschreibung
In Vitro
pNPPT (compound 2a) cyclohexanamine is efficiently hydrolyzed by wild-type PP1γ, with a maximum catalytic efficiency of 31 M-1s-1 and a second-order rate acceleration ratio of 1.7 × 1011. The transition state is characterized by restricted leaving group bond cleavage and effective general acid neutralization of the leaving group. The hydrolysis catalytic efficiency decreases for the PP1 R96K and PP1 R221K single mutants of PP1γ, with corresponding catalytic efficiency values of 0.8 M-1s-1 and 1.9 M-1s-1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS. Nr. 167698-72-8
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Molecular Weight 433.50
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Formel C18H32N3O5PS
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SMILES
O=P(O)(S)OC(C=C1)=CC=C1[N+]([O-])=O.NC2CCCCC2.NC3CCCCC3
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Synonyms
p-Nitrophenyl phosphorothioate cyclohexanamine
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
pNPPT cyclohexanamine Related Classifications
HY-187648 Related Classifications
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