ABL1
ABL1 is a non-receptor tyrosine kinase with SH3, SH2, and kinase domains, an F-actin binding region, and nuclear localization signals that permit shuttling between cytoplasm and nucleus. Autoinhibition is maintained through intramolecular interactions of the SH3 domain and an N-terminal myristoyl switch, a structural feature exploited by allosteric inhibitors. ABL1 participates in DNA-damage responses, cell adhesion, and cytoskeletal remodeling. Its clinical prominence arises from the Philadelphia chromosome translocation, which fuses BCR to ABL1 and generates a constitutively active kinase driving chronic myeloid leukemia and a subset of acute lymphoblastic leukemia, treatable with imatinib and subsequent-generation inhibitors.
-
ABL1 Recombinant Proteins (8)
-
Inhibitors & Agonists (259)
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
