BCKDK
BCKDK is a mitochondrial matrix kinase of the PDHK family that specifically switches off branched-chain alpha-ketoacid dehydrogenase (BCKDH), the rate-limiting complex of BCAA catabolism. It phosphorylates the E1alpha subunit of BCKDH at the same regulatory serines that the PDK isozymes use on pyruvate dehydrogenase, thereby coupling oxidation of leucine, valine and isoleucine to nutritional state. Its activity is stimulated by ATP and by alpha-ketoisovalerate and inhibited by alpha-ketoisocaproate. Reduced BCKDK expression leads to underphosphorylated, hyperactive BCKDH and elevated plasma BCAA levels. Recombinant BCKDK enables assays of BCAA metabolic control and inhibitor discovery.
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BCKDK Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
