CD5L
CD5L, also called Spα or AIM (apoptosis inhibitor of macrophages), is a secreted scavenger receptor cysteine-rich protein structurally related to the extracellular domains of CD5 and CD6 but lacking any membrane anchor. Produced mainly by tissue macrophages, it circulates in serum bound to IgM and contributes to apoptotic cell clearance and inflammatory restraint. CD5L binds fatty acid synthase in macrophages, reprogramming lipid metabolism toward inflammatory fatty acid synthesis and thereby shaping macrophage polarization. In mice, CD5L deficiency exacerbates autoimmunity and alters host defense, while in humans the protein has been linked to obesity-related inflammation and to IgM-containing circulating complexes. Recombinant CD5L has been explored as an anti-inflammatory biologic.
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CD5L Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
