IgG4
IgG4 is the scarcest human IgG subclass and behaves as the least inflammatory member of the family: it binds C1q negligibly and interacts only weakly with activating Fc gamma receptors, making it poorly inflammatory despite robust antigen binding. Unique among antibodies, IgG4 undergoes Fab-arm exchange through dynamic hinge disulfide reshuffling, generating bispecific molecules that further dampen immune-complex formation. IgG4 dominates responses to chronic allergen and helminth exposure and defines IgG4-related disease, a fibroinflammatory condition. Because of its low effector profile, an IgG4 Fc bearing the stabilizing S228P mutation is the scaffold for checkpoint inhibitors such as nivolumab and pembrolizumab.
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IgG4 Recombinant Proteins (2)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
