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Art. -Nr.: HY-126972

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RI(dl)-2

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

RI(dl)-2 blocks RAD51’s D-loop activity in biochemical systems with an IC₅₀ value of 11.1 µM and inhibits homologous recombination (HR) activity with an IC₅₀ value of 3.0 µM. RI(dl)-2 inhibits HR-mediated repair of DNA double strand breaks and sensitizes different cancer cell lines.

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CAS. Nr.: 1902146-75-1
Formel: C₁₉H₁₇N₃
Molecular Weight:287.36

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Data Sheet (267 KB)

RI(dl)-2 Chemical Structure

CAS. Nr.: 1902146-75-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Chemical Information

CAS. Nr. 1902146-75-1
Molecular Weight 287.36
Formel C₁₉H₁₇N₃
SMILES

CCNC(C=C1)=CC=C1C2=NC3=C(N4C=CC=C42)C=CC=C3
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.

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Nat Cell Biol

Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage. [Abstract]

2025 Jan;27(1):59-72. PMID: 39805921

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Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wei Lv, et al. Development of Small Molecules that Specifically Inhibit the D-loop Activity of RAD51. J Med Chem. 2016 May 26;59(10):4511-25. [Content Brief]

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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RI(dl)-2

1 Cited Publications

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RI(dl)-2

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Publications (1)

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RI(dl)-2 Related Classifications

HY-126972 Related Classifications