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Art. -Nr.: HY-147222

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SAE-14

(Synonyms: GPR183 antagonist-1)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC₅₀ value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC₅₀ value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice.

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Reinheit: 98.60%
CAS. Nr.: 1241280-25-0
Formel: C₁₉H₁₉F₃N₂O₂
Molecular Weight:364.36

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

SAE-14 Chemical Structure

CAS. Nr.: 1241280-25-0

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: 28.5 nM (GPR183)^[1]

In Vitro

SAE-14 (compound SAE-14) can able to antagonize 7α, 25-OHC–induced calcium mobilization with an IC₅₀ value below 50 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

The human leukemia (HL)-60 cells
Concentration:

5×of the antagonist
Incubation Time:

15 min
Result:

Had GPR183-specific (IC₅₀: 28.5nM) and abolished 7a, 25-OHC–induced calcium mobilization in the HL-60 cells.

In Vivo

SAE-14 (compound SAE-14) (i.th.; 2.9 μM; once) can reverse nerve injury-induced allodynia in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male and female ICR mice^[1]
Dosage:

2.9 µM
Administration:

intrathecal (i.th.) injections; 2.9 µM; once
Result:

Reversed CCI-induced mechanical allodynia in a time-dependent manner.

Chemical Information

CAS. Nr. 1241280-25-0
Appearance Solid
Molecular Weight 364.36
Formel C₁₉H₁₉F₃N₂O₂
Color White to off-white
SMILES

O=C(NC1=CC(N2CCOCC2)=CC(F)=C1)CCC3=CC=C(F)C(F)=C3
Synonyms

GPR183 antagonist-1
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Eur J Pharmacol

Activation of G-protein-coupled receptor 183 initiates inflammatory pain via macrophage CCL22 secretion. [Abstract]

2023 Jun 21;954:175872. PMID: 37353188

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (274.45 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7445 mL

13.7227 mL

27.4454 mL

5 mM

0.5489 mL

2.7445 mL

5.4891 mL

10 mM

0.2745 mL

1.3723 mL

2.7445 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kathryn Braden, et al. GPR183-Oxysterol Axis in Spinal Cord Contributes to Neuropathic Pain. J Pharmacol Exp Ther. 2020 Nov;375(2):367-375. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.7445 mL	13.7227 mL	27.4454 mL	68.6135 mL
	5 mM	0.5489 mL	2.7445 mL	5.4891 mL	13.7227 mL
	10 mM	0.2745 mL	1.3723 mL	2.7445 mL	6.8613 mL
	15 mM	0.1830 mL	0.9148 mL	1.8297 mL	4.5742 mL
	20 mM	0.1372 mL	0.6861 mL	1.3723 mL	3.4307 mL
	25 mM	0.1098 mL	0.5489 mL	1.0978 mL	2.7445 mL
	30 mM	0.0915 mL	0.4574 mL	0.9148 mL	2.2871 mL
	40 mM	0.0686 mL	0.3431 mL	0.6861 mL	1.7153 mL
	50 mM	0.0549 mL	0.2745 mL	0.5489 mL	1.3723 mL
	60 mM	0.0457 mL	0.2287 mL	0.4574 mL	1.1436 mL
	80 mM	0.0343 mL	0.1715 mL	0.3431 mL	0.8577 mL
	100 mM	0.0274 mL	0.1372 mL	0.2745 mL	0.6861 mL

Keywords

SAE-14

1 Cited Publications

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo Dissolution Calculator
Reinheit & Dokumentation
Verweise

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SAE-14

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) SAE-14

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

SAE-14

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) SAE-14

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

SAE-14 Related Classifications

Art. -Nr.: HY-147222