SCR005
SCR005 is a synthetic carbohydrate receptor (SCR) with broad-spectrum antiviral activity. SCR005 inhibits the entry of enveloped viruses across multiple families (Coronaviridae: SARS-CoV-1, SARS-CoV-2, MERS-CoV; Filoviridae: EBOV, MARV; Paramyxoviridae: NiV, HeV) and the glycosylated nonenveloped rotavirus. SCR005 binds viral envelope N-glycans, blocking viral binding to host cells or both binding and membrane fusion. SCR005 exerts prophylactic effects in hACE2 mice infected with SARS-CoV-2. SCR005 can be used for the study and prevention of enveloped virus pandemics.
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- CAS. Nr.: 2409183-70-4
- Formel: C36H34N8
- Molecular Weight:578.71
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| Vero | IC50 |
1.36 μM
Compound: SCR-7
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Antiviral activity against Zika virus harboring subgenomic GFP replicon infected in African green monkey Vero cells assessed as reduction in viral infection preincubated for 30 mins followed by viral infection and measured after 72 hrs
Antiviral activity against Zika virus harboring subgenomic GFP replicon infected in African green monkey Vero cells assessed as reduction in viral infection preincubated for 30 mins followed by viral infection and measured after 72 hrs
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[PMID: 30925051] |
In Vitro
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:hACE2 knock-in mice (4-5-month-old) were intranasally challenged with 2 × 103 PFU of SARS-CoV-1/2[1]
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Dosage:3 mg/kg
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Administration:i.n., single dose
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Result:Improved survival rate to 30%.
Decreased lung and brain viral RNA copies by multiple orders of magnitude.
Reduced perivascular infiltrates and necrotic neurons in lung and brain tissues.
Decreased pro-inflammatory cytokine levels in bronchoalveolar lavage fluid (BALF), with IL-18 and IFN-γ reduced.
Chemical Information
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CAS. Nr. 2409183-70-4
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Molecular Weight 578.71
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Formel C36H34N8
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SMILES
C1(C/N=C/C2=CC=CN2)=CC(C3=CC(C/N=C/C4=CC=CN4)=CC(C/N=C/C5=CC=CN5)=C3)=CC(C/N=C/C6=CC=CN6)=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
SCR005 Related Classifications
HY-178135 Related Classifications
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