8565 Results for "

multimer binding intensity

" in MedChemExpress (MCE) Product Catalog:
Products (8565)

8565 Results for "multimer binding intensity" in MCE Product Catalog:

645
ML385
ML385
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645 Publications Verification
Art. -Nr.: HY-100523
CAS. Nr.: 846557-71-9
Reinheit:  99.96%
Target:  

Keap1-Nrf2 Ferroptosis Apoptosis mTOR

Forschungsgebiete:  

Cardiovascular Disease Cancer

ML385 is a potent and selective Nrf2 inhibitor with an IC50 of 1.9 μM. ML385 directly binds to the Neh1 domain of NRF2, interferes with the binding of the MAFG-NRF2 protein complex to the antioxidant response element (ARE) DNA sequence, thereby blocking the expression of downstream target genes of NRF2. ML385 can be used in studies related to adult T-cell leukemia, breast cancer, myocardial ischemia/reperfusion injury, non-small cell lung cancer, esophageal squamous cell carcinoma, head and neck squamous cell carcinoma, and lung squamous cell carcinoma .
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427
PD98059
PD98059
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427 Cited Publications
Art. -Nr.: HY-12028
CAS. Nr.: 167869-21-8
Reinheit:  98.89%
Target:  

MEK ERK Aryl Hydrocarbon Receptor Autophagy

Forschungsgebiete:  

Cancer

PD98059 is a potent and selective MEK inhibitor with an IC50 of 5 µM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC50 of 2-7 µM) and MEK2 (IC50 of 50 µM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC50 of 4 μM) and AHR transformation (IC50 of 1 μM). PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG)-induced autophagy .
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324
Stattic
Stattic
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324 Cited Publications
Art. -Nr.: HY-13818
CAS. Nr.: 19983-44-9
Reinheit:  99.58%
Target:  

STAT Apoptosis

Forschungsgebiete:  

Inflammation/Immunology Cancer

Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727) . Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3 . Stattic ameliorates the renal dysfunction in Alport syndrome (AS) mice .
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186
DAPI dihydrochloride
DAPI dihydrochloride
0 Images
186 Cited Publications
Art. -Nr.: HY-D0814
CAS. Nr.: 28718-90-3
Synonyms: 4',6-Diamidino-2-phenylindole dihydrochloride
DAPI (4',6-Diamidino-2-phenylindole) dihydrochloride is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).
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186
DAPI
DAPI
0 Images
186 Cited Publications
Art. -Nr.: HY-D2868
CAS. Nr.: 47165-04-8
Synonyms: 4',6-Diamidino-2-phenylindole
DAPI (4',6-Diamidino-2-phenylindole) is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm).
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180
DAPI dilactate
DAPI dilactate
0 Images
180 Cited Publications
Art. -Nr.: HY-D1738
CAS. Nr.: 28718-91-4
Synonyms: 4',6-Diamidino-2-phenylindole dilactate
DAPI (4',6-Diamidino-2-phenylindole) dilactate is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining damaged and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm) .
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165
Hoechst 33342
Hoechst 33342
0 Images
165 Cited Publications
Art. -Nr.: HY-15559
CAS. Nr.: 23491-52-3
Reinheit:  99.94%
Synonyms: bisBenzimide H 33342; HOE 33342
Hoechst 33342 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
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165
Hoechst 33342 trihydrochloride
Hoechst 33342 trihydrochloride
0 Images
165 Cited Publications
Art. -Nr.: HY-15559A
CAS. Nr.: 875756-97-1
Reinheit:  99.81%
Synonyms: bisBenzimide H 33342 trihydrochloride; HOE 33342 trihydrochloride
Hoechst 33342 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
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139
Curcumin
Curcumin
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139 Cited Publications
Art. -Nr.: HY-N0005
CAS. Nr.: 458-37-7
Synonyms: Diferuloylmethane; Natural Yellow 3; Turmeric yellow
Category:  

Anti-aging Zingiberaceae Extract Plants Food Research Sunscreen Pigments Phenols Polyphenols Cosmetic Research Curcuma longa Disease Research Fields Cancer

Target:  

Histone Acetyltransferase Epigenetic Reader Domain Keap1-Nrf2 Autophagy Mitophagy Influenza Virus Ferroptosis Apoptosis

Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin is a photosensitizer against microorganisms. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.
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131
Imatinib
Imatinib
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131 Cited Publications
Art. -Nr.: HY-15463
CAS. Nr.: 152459-95-5
Reinheit:  99.95%
Synonyms: STI571; CGP-57148B
Target:  

Bcr-Abl PDGFR c-Kit SARS-CoV Autophagy

Forschungsgebiete:  

Cancer

Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively . Imatinib also is an inhibitor of SARS-CoV and MERS-CoV .
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124
Palmitic acid
Palmitic acid
0 Images
124 Cited Publications
Art. -Nr.: HY-N0830
CAS. Nr.: 57-10-3
Category:  

Cardiovascular Disease Natural Products Neurological Disease Plants Other Families Extract Endogenous metabolite Biological Pesticide Research Agricultural Research Human Gut Microbiota Metabolites Microorganisms Animals Disease Research Fields Cancer

Target:  

Environmental Pollutants Endogenous Metabolite HSP

Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid is used to establish a cell steatosis model .
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124
Palmitic acid sodium
Palmitic acid sodium
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124 Cited Publications
Art. -Nr.: HY-N0830B
CAS. Nr.: 408-35-5
Palmitic acid sodium is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid sodium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid sodium is used to establish a cell steatosis model .
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123
CH-223191
CH-223191
0 Images
123 Cited Publications
Art. -Nr.: HY-12684
CAS. Nr.: 301326-22-7
Reinheit:  99.96%
Target:  

Aryl Hydrocarbon Receptor

Forschungsgebiete:  

Cancer

CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR). CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM .
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109
T-5224
T-5224
0 Images
109 Cited Publications
Art. -Nr.: HY-12270
CAS. Nr.: 530141-72-1
Reinheit:  99.03%
Target:  

AP-1 MMP

Forschungsgebiete:  

Neurological Disease Inflammation/Immunology Cancer

T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .
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108
Tacrolimus
Tacrolimus
0 Images
108 Cited Publications
Art. -Nr.: HY-13756
CAS. Nr.: 104987-11-3
Reinheit:  99.93%
Synonyms: FK506; Fujimycin; FR900506
Category:  

Infection Microorganisms Animals Macrolide Antibiotics Anti-inflammation/Immunoregulatory Antibiotics Disease Research Disease Research Fields Inflammation/Immunology

Target:  

Phosphatase FKBP Molecular Glues Bacterial Autophagy Antibiotic

Tacrolimus (FK506), a molecular glue, a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .
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108
Tacrolimus monohydrate
Tacrolimus monohydrate
0 Images
108 Cited Publications
Art. -Nr.: HY-13756A
CAS. Nr.: 109581-93-3
Reinheit:  99.67%
Synonyms: FK506 monohydrate; Fujimycin monohydrate; FR900506 monohydrate
Category:  

Infection Microorganisms Macrolide Antibiotics Anti-inflammation/Immunoregulatory Antibiotics Disease Research Disease Research Fields Inflammation/Immunology

Target:  

Phosphatase FKBP Molecular Glues Bacterial Autophagy Antibiotic

Tacrolimus (FK506) monohydrate, a molecular glue, a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus monohydrate inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .
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104
Cytochalasin D
Cytochalasin D
0 Images
104 Cited Publications
Art. -Nr.: HY-N6682
CAS. Nr.: 22144-77-0
Synonyms: Zygosporin A; NSC 209835
Category:  

Infection Natural Products Microorganisms Disease Research Fields

Target:  

Exosomes Arp2/3 Complex Antibiotic YAP

Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap .
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93
AS1842856
AS1842856
0 Images
93 Cited Publications
Art. -Nr.: HY-100596
CAS. Nr.: 836620-48-5
Reinheit:  99.88%
Target:  

Autophagy

Forschungsgebiete:  

Metabolic Disease

AS1842856, a specific Foxo1 inhibitor (IC50=30 nM), potently suppresses autophagy . AS1842856 reduces Foxo1 activity and, to a lesser extent, inhibits Foxo1 protein expression by simply binding to Foxo1 .
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88
Irinotecan
Irinotecan
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88 Cited Publications
Art. -Nr.: HY-16562
CAS. Nr.: 97682-44-5
Synonyms: (+)-Irinotecan; CPT-11; VAL-413free base
Target:  

Topoisomerase Autophagy

Forschungsgebiete:  

Neurological Disease Cancer

Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .
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87
Capsaicin
Capsaicin
0 Images
87 Cited Publications
Art. -Nr.: HY-10448
CAS. Nr.: 404-86-4
Reinheit:  99.79%
Synonyms: (E)-Capsaicin
Category:  

Capsicum annuum L. Monophenols Phenols Plants Disease Research Fields Biological Pesticide Research Cancer Solanaceae Extract Agricultural Research

Target:  

Environmental Pollutants TRP Channel Autophagy Endogenous Metabolite Apoptosis

Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin induces a nociceptive response by binding to its receptors. Capsaicin has analgesic effects on neurological disorders. Capsaicin has antioxidant, anti-inflammatory, anti-cancer effects .
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