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AS1842856

92 Cited Publications
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Based on 92 publication(s) in Google Scholar

AS1842856, a specific Foxo1 inhibitor (IC50=30 nM), potently suppresses autophagy. AS1842856 reduces Foxo1 activity and, to a lesser extent, inhibits Foxo1 protein expression by simply binding to Foxo1.

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  • Reinheit: 99.88%
  • CAS. Nr.: 836620-48-5
  • Formel: C18H22FN3O3
  • Molecular Weight:347.38
  • Speicherung:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • AS1842856 Chemical Structure
    AS1842856 Chemical Structure
  • Experimental Validation Results for AS1842856
  • Experimental Validation Results for AS1842856
  • Experimental Validation Results for AS1842856
  • Experimental Validation Results for AS1842856
  • Experimental Validation Results for AS1842856
CAS. Nr.: 836620-48-5
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  • AS1842856 Chemical Structure
    AS1842856 Chemical Structure
    1/16
  • 1/16

    AS1842856 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Aug:74:493-511. [Abstract]

    Customer Validation
     Based on the FOXO1 inhibitor (AS1842856) (10 μM; 48 h) and UFL1-KO cells, Western blot was used to detect the influence of FOXO1 on the ability of UFL1 to regulate COL1.

  • 1/16

    AS1842856 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Jun;52:102311. [Abstract]

    Customer Validation
     The mice were then treated with the FoxO1 inhibitor AS1842856 at a dosage of 100 mg/kg by oral gavage twice daily for two days immediately following each Dox injection. Representative blots and quantitative data of Mfn2 protein levels were shown.

  • 1/16

    AS1842856 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Jun;52:102311. [Abstract]

    Customer Validation
     The mice were then treated with FoxO1 inhibitor AS1842856 at the dosage of 100 mg/kg by oral gavage twice daily for two days immediately following each Dox injection. Representative mitochondrial images were obtained by transmission electron microscopy.

  • 1/16

    AS1842856 purchased from MedChemExpress. Usage Cited in: Mol Cell Biochem. 2023 Jul;478(7):1561-1571. [Abstract]

    Customer Validation
     AS1842856 (1 μM; 48 h) reverses CEP55 downregulation-mediated inhibition of PCNA and CDK2 levels and elevation of cl-caspase-3 expression in Ishikawa and RL95-2 cells.

  • 1/16

    AS1842856 purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Jul 25;11(18):8624-8639. [Abstract]

    Customer Validation
     AS group that received an infusion of FoxO1 inhibitor AS1842856 (AS, 20 mg/kg/day) was studied. Representative Western blot images of LC3, Beclin1, and p62 expressions in the myocardium of five groups of mice were shown.

  • AS1842856