Semorinemab
Based on 1 Customer Validation
Semorinemab (RG 6100) is an anti-Tau humanized IgG4 monoclonal antibody, targets the N-terminal portion of the Tau protein (amino acid residues 6-23). Semorinemab binds with human Tau with a Kd value of 3.8 nM. Semorinemab can be used for the research of Alzheimer's Disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.36%
- CAS. Nr.: 2159141-27-0
- Molecular Weight:145.1 kDa
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biologische Aktivität
Beschreibung
Isotype
Human IgG4 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
Tau
In Vitro
Semorinemab binds to human Tau and recombinant cynomolgus monkey Tau with Kd values of 3.8 and 11.2 nM, respectively[1]. Semorinemab prevents neurons to uptake oligomeric Tau[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Tg mouse with the expression of human disease-causing tau mutant (TauP301L-Tg) [1]
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Dosage:3, 10 and 30 mg/kg
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Administration:Intraperitoneal injection; 3, 10 and 30 mg/kg, once weekly for 13 weeks
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Result:Reduced the accumulation of pathological tau, and dose-dependently decreased pTau212/214 and pTau202/205.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG4 kappa
Anwendung
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized Human Tau Protein (His Tag) can bind Semorinemab. The EC50 for this effect is 4.02 ng/mL. -
Flow cytometric analysis of 1.5X106 SHSY5Y cells with Semorinemab (HY-P99399, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa, Isotype Control (HY-P99003, blue) was used as the isotype control.
Chemical Information
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CAS. Nr. 2159141-27-0
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Appearance Liquid
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Molecular Weight 145.1 kDa
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Color Colorless to light yellow
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SMILES
[Semorinemab]
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Synonyms
RG 6100; RO7105705; MTAU-9937A
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Versand
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
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Data Sheet (259 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)