SM-11044
SM-11044 is a β-adrenoceptor agonist with Ki values of 18.1 μM (β1), 4.1 μM (β2) and 1.3 μM (β3), showing higher binding selectivity for the β3-adrenoceptor. SM-11044 stimulates cAMP accumulation in cells expressing this receptor. SM-11044 mediates ileal relaxation, tracheal relaxation, pulmonary parenchymal relaxation, increased right atrial heart rate and adipocyte lipolysis.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 142784-65-4
- Formel: C22H28BrFN2O4
- Molecular Weight:483.37
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Alle Adrenergic Receptor Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
|
β1 adrenoceptor 18.1 μM (Ki) |
β2 adrenoceptor 4.1 μM (Ki) |
β3 adrenoceptor 1.3 μM (Ki) |
SM-11044 (Serial dilutions; 1 h) binds to β1-, β2-, and β3-adrenoceptors expressed in CHO cells with highest affinity for β3-adrenoceptors (Ki = 1 μM), followed by β2-adrenoceptors (Ki = 4 μM), and lowest affinity for β1-adrenoceptors (Ki = 18 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 142784-65-4
-
Molecular Weight 483.37
-
Formel C22H28BrFN2O4
-
SMILES
O[C@H](C1=CC(O)=C(C=C1)O)[C@H](NCCCC2=CC=C(C=C2)F)C(N3CCCC3)=O.Br
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
SM-11044 Related Classifications
HY-182640 Related Classifications
Powered by Bioz