SMU-B
SMU-B is the orally active inhibitor for ALK (IC50<0.5 nM), c-ros oncogene 1 (ROS1), c-MET (IC50=1.87 nM) and AXL (IC50=28.9 nM). SMU-B inhibits the proliferation of MKN45, H1993 and H441 with IC50s of 0.02 μM, 1.58 μM and 2.82 μM, respectively. SMU-B exhibits antitumor efficacy in mouse models.
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- CAS. Nr.: 1253286-90-6
- Formel: C26H25Cl2FN4O2
- Molecular Weight:515.41
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
IC50: <5 nM (ALK); 1.87 nM (c-MET); 28.9 nM (AXL)
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| GTL 16 cell line | IC50 |
0.02 μM
Compound: 5b, (SMU-B)
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Antiproliferative activity against human GTL16 cells after 48 hrs by MTT assay
Antiproliferative activity against human GTL16 cells after 48 hrs by MTT assay
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[PMID: 24900750] |
| NCI-H1993 | IC50 |
1.58 μM
Compound: 5b, (SMU-B)
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Antiproliferative activity against human NCI-H1993 cells after 48 hrs by MTT assay
Antiproliferative activity against human NCI-H1993 cells after 48 hrs by MTT assay
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[PMID: 24900750] |
| NCI-H441 | IC50 |
2.82 μM
Compound: 5b, (SMU-B)
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Antiproliferative activity against human H441 cells after 48 hrs by MTT assay
Antiproliferative activity against human H441 cells after 48 hrs by MTT assay
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[PMID: 24900750] |
| U-87MG ATCC | IC50 |
>10 μM
Compound: 5b, (SMU-B)
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Antiproliferative activity against human U87MG cells after 48 hrs by MTT assay
Antiproliferative activity against human U87MG cells after 48 hrs by MTT assay
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[PMID: 24900750] |
Chemical Information
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CAS. Nr. 1253286-90-6
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Molecular Weight 515.41
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Formel C26H25Cl2FN4O2
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SMILES
O=C1NC2=C(C=CC(C3=CC(O[C@@H](C4=C(Cl)C=CC(F)=C4Cl)C)=C(N)N=C3)=C2)C15CCN(C)CC5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Tian Y, et al., Molecular Simulation Studies on the Binding Selectivity of Type-I Inhibitors in the Complexes with ROS1 versus ALK. J Chem Inf Model. 2017 Apr 24;57(4):977-987. [Content Brief]
[2]. Li J, et al., Aminopyridyl/Pyrazinyl Spiro[indoline-3,4'-piperidine]-2-ones As Highly Selective and Efficacious c-Met/ALK Inhibitors. ACS Med Chem Lett. 2013 Jul 12;4(8):806-10. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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