SOAT-IN-2
SOAT-IN-2 is a selective sodium-dependent organic anion transporter (SOAT, SLC10A6) inhibitor. SOAT-IN-2 blocks sodium-dependent cellular uptake of sulfated steroid Dehydroepiandrosterone sulfate (DHEAS, HY-113416). SOAT-IN-2 reduces intracellular estradiol synthesis, DHEA (HY-14650) formation, and DHEAS-stimulated cancer cell proliferation without inducing cytotoxicity. SOAT-IN-2 can be used for the research of breast cancer.
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- CAS. Nr.: 3056727-95-5
- Formel: C19H12Cl3N3O5S
- Molecular Weight:500.74
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
SOAT-IN-2 (compound 12) (10 μM; 5 min preincubation) potently inhibits sodium-dependent SOAT-mediated [3H]DHEAS uptake in MCF-7_SOAT cells[1].
SOAT-IN-2 (10 μM; 10 min preincubation, 3 days combined treatment with 10 μM DHEAS) completely suppresses DHEAS-stimulated proliferation in MCF-7_SOAT cells[1].
SOAT-IN-2 (10 μM; 30 min preincubation, 72 h combined treatment with 10 μM DHEAS) significantly reduces DHEAS-derived DHEA and estradiol formation in MCF-7_SOAT cells[1].
SOAT-IN-2 inhibits SOAT-mediated DHEAS transport in SOAT-transfected HEK293 cells with an IC50 of 1.9 μM[1].
SOAT-IN-2 (0.1-10 μM; 24 h) is non-cytotoxic to MCF-7_FRT and MCF-7_SOAT cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SOAT-overexpressing MCF-7 breast cancer cells (MCF-7_SOAT)
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Concentration:10 μM
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Incubation Time:10 min
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Result:Had no effect on MCF-7_SOAT cell proliferation.
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Cell Line:SOAT-overexpressing MCF-7 breast cancer cells (MCF-7_SOAT)
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Concentration:10 μM plus 10 μM DEHA
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Incubation Time:3 days
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Result:Completely abolished the DHEAS-stimulated proliferation of MCF-7_SOAT cells, reducing proliferation to baseline control levels when combined with DHEAS.
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Cell Line:SOAT-overexpressing MCF-7 breast cancer cells (MCF-7_SOAT), control MCF-7_FRT cells
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Concentration:0.1 μM; 10 μM
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Incubation Time:24 h
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Result:Did not induce LDH release in either MCF-7_FRT or MCF-7_SOAT cells, indicating no cytotoxicity under these conditions.
Chemical Information
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CAS. Nr. 3056727-95-5
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Molecular Weight 500.74
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Formel C19H12Cl3N3O5S
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SMILES
O=S(C1=CC=CC([N+]([O-])=O)=C1)(NC2=C(C(NC3=CC(Cl)=C(Cl)C=C3)=O)C=C(Cl)C=C2)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
SOAT-IN-2 Related Classifications
HY-182767 Related Classifications
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